dc.creatorTéllez Castillo N.
dc.creatorSiachoque Jara J.J.
dc.creatorSiachoque Jara J.S.
dc.creatorSiachoque Jara M.A.
dc.creatorSiachoque Montañez H.O.
dc.date.accessioned2020-05-25T23:59:38Z
dc.date.accessioned2022-09-22T14:12:40Z
dc.date.available2020-05-25T23:59:38Z
dc.date.available2022-09-22T14:12:40Z
dc.date.created2020-05-25T23:59:38Z
dc.identifier01218123
dc.identifier20279000
dc.identifierhttps://repository.urosario.edu.co/handle/10336/23078
dc.identifierhttps://doi.org/10.1016/j.rcreu.2017.07.002
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3436805
dc.description.abstractThe activation of T cells is initiated by the presentation of exogenous or endogenous antigens, by antigen presenting cells through the major histocompatibility complex, which binds to a special receptor on T cells. This acknowledgement triggers a cascade of intracellular signalling that leads to an increase in integrin expression, cytoskeletal modifications, and transcription factors production involved in the liberation of cytokines and inflammatory mediators. One of the most important inducers in cell activation is the enzymatic complex with tyrosine kinase action. The kinases which belong to the SRC (SFK) LCK and FYN family have been involved in a large number of important processes in the activation and modulation of the T cells response, as well as in the development of autoimmune diseases. Regulating the kinases signalling, as well as the adapter proteins involved in T cell activation, is essential for maintaining an activation threshold, as well as the modulation of cell response. The phosphorylation of the positive regulation sites of these proteins is important to allow an active configuration of the protein and thereby its maximum capacity as kinase. The phosphorylation of negative regulation sites leads to a closed configuration of the protein that reduces its kinase function, and thereby inhibits its own function. The alteration in signalling by the modification of certain cytoplasmic proteins in some cases is associated with the development of autoimmune diseases, such as systemic lupus erythematosus. Under physiological conditions the T cell receptor complex regroups with protein complexes that interact harmonically to generate an internal signal. The altered signalling events are partly responsible for an anomalous expression of cytokines, including the interleukin-6 (IL-6), IL-10, IL-2, IFN, and CD40 linking, these modifications affects the cells ability to over-stimulate T and B cells, resulting in an increased production of autoantibodies and the triggering of the autoimmune disease. © 2017 Asociación Colombiana de Reumatología
dc.languagespa
dc.publisherAsociacion Colombiana de Reumatologia
dc.relationRevista Colombiana de Reumatologia, ISSN:01218123, 20279000, Vol.25, No.1 (2018); pp. 38-54
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85044129162&doi=10.1016%2fj.rcreu.2017.07.002&partnerID=40&md5=7523e65d8297745278e6bb0cc31a3a3c
dc.relation54
dc.relationNo. 1
dc.relation38
dc.relationRevista Colombiana de Reumatologia
dc.relationVol. 25
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAbierto (Texto Completo)
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleT-cell activation, alterations in systemic lupus erythematosus: A narrative review
dc.typearticle


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