Efectividad y seguridad del plasma rico en plaquetas en comparación con otras alternativas de tratamiento para la epicondilitis lateral

Abstract

Introduction: Lateral epicondylitis (LE) is the most diagnosed tendinopathy, with a prevalence between 1-3% in the general population and up to 7% in people exposed to the repetitive forearm and wrist movements, leading to limitation and loss of capacity functional. Its management is mainly conservative, however, due to advances in research and molecular medicine, the use of platelet-rich plasma is considered today as an innovative alternative. Objective: To Determine the effectiveness and safety of the use of Platelet Rich Plasma in the management of lateral epicondylitis in comparison with the other management alternatives described. Methodology: A Systematic Review was carried out following the Cochrane Collaboration standard. The Embase, Medline, Lilacs, and Cochrane databases were consulted. The search strategy based on the PICO question was built using standardized terms Mesh, Decs, and Emtree according to the database, as well as free terms, without any type of restriction or limits. References were selected through an independent paired review of titles and abstracts, as well as quality assessment and extraction of information from the studies. The summary of the evidence followed the GRADE recommendations and the methodological quality assessed according to the design. Results: The results on pain in the relation significant differences in favor of the Platelet Rich Plasma (PRP) in relation to multiple pooled comparators. When specifically compared to placebo and whole blood, significant differences were only found in favor of PRP in the short term. On the contrary, when comparing with steroids and local anesthetics, significant differences were found in favor of PRP in the medium and long term. The results show that the PRP was superior to the control in terms of functionality when evaluated with Patient Rated Tennis Elbow Evaluation Scale (PRTEE) at 6 months. The other comparisons did not change significantly.