dc.creator | Cristancho, Diana | |
dc.date.accessioned | 2019-06-29T11:04:44Z | |
dc.date.available | 2019-06-29T11:04:44Z | |
dc.date.created | 2019-06-29T11:04:44Z | |
dc.date.issued | 2011 | |
dc.identifier | https://repositorio.unal.edu.co/handle/unal/50929 | |
dc.identifier | http://bdigital.unal.edu.co/44971/ | |
dc.description.abstract | Thermodynamic functions Gibbs energy, enthalpy, and entropy of mixing of propranolol hydrochloride in ethanol + water mixtures were evaluated. Mixing quantities were calculated based on fusion calorimetric values obtained from differential scanning calorimetry measurements and equilibrium solubility values reported in the literature for this drug in these cosolvent mixtures. By means of enthalpy-entropy compensation analysis, a non-linear ∆ mix H° vs. ∆ G° plot was obtained indicating different mechanisms involved in the dissolution and mixing of this drug according to mixtures composition. Nevertheless, the molecular and ionic events involved in the dissolution of this drug in this cosolvent system are unclear. | |
dc.language | spa | |
dc.publisher | Revista Colombiana de Ciencias Químico Farmacéuticas | |
dc.relation | Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas | |
dc.relation | Revista Colombiana de Ciencias Químico Farmacéuticas | |
dc.relation | Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 40, núm. 2 (2011) 0034-7418 1909-6356 | |
dc.relation | Cristancho, Diana (2011) Thermodynamics of mixing of the -adrenergic blocker propranolol-hcl in ethanol + water mixtures. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 40, núm. 2 (2011) 0034-7418 1909-6356 . | |
dc.relation | http://revistas.unal.edu.co/index.php/rccquifa/article/view/45586 | |
dc.rights | Atribución-NoComercial 4.0 Internacional | |
dc.rights | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Derechos reservados - Universidad Nacional de Colombia | |
dc.title | Thermodynamics of mixing of the -adrenergic blocker propranolol-hcl in ethanol + water mixtures | |
dc.type | Artículo de revista | |