Mechanobiological approach for skeletal muscle adaptation

dc.contributorGarzón Alvarado, Diego Alexander
dc.contributorRamírez Martínez, Angélica María
dc.contributorRöhrle, Oliver
dc.contributorGnum Grupo de Modelado y Métodos Numericos en Ingeniería
dc.creatorVillota Narváez, Yesid Alexis
dc.date.accessioned2022-07-22T15:59:36Z
dc.date.available2022-07-22T15:59:36Z
dc.date.created2022-07-22T15:59:36Z
dc.date.issued2022
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/81728
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.description.abstractSkeletal muscle is the most adaptive tissue in the human body. Its adaptation includes changes in shape and size, changes at the organelle function and distribution inside muscle cells, and changes at the molecular scale. Macroscopic characteristics such as size and strength, are related to the cellular scale via protein content in myofibrils, which are the series arrangement of units that generate force (sarcomeres); at the organelle scale, adaptation occurs in the mytochondria content, as well as sarcoplasmic reticulum function; microscopic characteristics at the molecular scale are related to the type of protein molecules that myofibrils contain, the type of molecules include a variety of myosin heavy and light chains. This adaptation processes are the outcome of stimulus like diet, hormone levels, and physical activity. The last one will be particularly important for the aim of this thesis, which is the modeling of the evolution of the characteristics of muscle tissue under the effects of personalized training protocols, i.e. physical activity.
dc.description.abstractEl músculo esquelético es el tejido más adaptable del cuerpo humano. Su adaptación incluye cambios en la forma y el tamaño, cambios en la función y distribución de los organelos dentro de las células musculares y cambios a escala molecular. Las características macroscópicas, como el tamaño y la fuerza, están relacionadas con la escala celular a través del contenido de proteínas en las miofibrillas, que son la disposición en serie de las unidades que generan la fuerza (sarcómeros); a escala de los organelos, la adaptación se produce en el contenido de las mitocondrias, así como en la función del retículo sarcoplásmico; las características microscópicas a escala molecular están relacionadas con el tipo de moléculas de proteínas que contienen las miofibrillas. El tipo de moléculas incluye una variedad de cadenas pesadas y ligeras de miosina. Los procesos de adaptación son el resultado de estímulos como la dieta, los niveles hormonales y la actividad física. Este último será especialmente importante para el objetivo de esta tesis, que es el modelamiento de la evolución de las características del tejido muscular bajo los efectos de protocolos de entrenamiento personalizados, es decir, la actividad física. (Texto tomado de la fuente)
dc.description.abstractDer Skelettmuskel ist das anpassungsf¨ahigste Gewebe im menschlichen K¨orper. Zu seiner Anpassung geh¨oren Ver¨anderungen in Form und Gr¨oße, Ver¨anderungen der Organellenfunktion und der Verteilung innerhalb der Muskelzellen sowie Ver¨anderungen auf molekularer Ebene. Makroskopische Merkmale wie Gr¨oße und St¨arke h¨angen mit der zellul¨aren Skala ¨uber den Proteingehalt in den Myofibrillen zusammen, d.h. der Reihenanordnung von Einheiten, die Kraft erzeugen (Sarkomere); auf der Organellenskala erfolgt die Anpassung im Mytochondriengehalt sowie in der Funktion des sarkoplasmatischen Retikulums; mikroskopische Merkmale auf der molekularen Skala h¨angen mit der Art der Proteinmolek¨ule zusammen, die die Myofibrillen enthalten, wobei die Art der Molek¨ule eine Vielzahl von schweren und leichten Myosinketten umfasst. Diese Anpassungsprozesse sind das Ergebnis von Reizen wie Ern¨ahrung, Hormonspiegel und k¨orperlicher Aktivit¨at. Letzteres wird f¨ur das Ziel dieser Arbeit besonders wichtig sein, n¨amlich die Modellierung der Entwicklung der Eigenschaften des Muskelgewebes unter den Auswirkungen personalisierter Trainingsprotokolle, d.h. k¨orperlicher Aktivit¨at.
dc.languageeng
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Ingeniería - Doctorado en Ingeniería - Ingeniería Mecánica y Mecatrónica
dc.publisherDepartamento de Ingeniería Mecánica y Mecatrónica
dc.publisherFacultad de Ingeniería
dc.publisherBogotá, Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
dc.relationRedCol
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dc.rightsAtribución-NoComercial-CompartirIgual 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMechanobiological approach for skeletal muscle adaptation
dc.typeTrabajo de grado - Doctorado


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