Expresión de receptores para la hormona luteinizante y su ácido ribonucléico mensajero en folículos preovulatorios de vacas Romosinuano y Brahman - posible relación con los niveles séricos de progesterona

dc.contributorHernández Vásquez, Aureliano
dc.contributorBiología de la adaptación animal al trópico - Genética y Biotecnología de la reproducción .
dc.creatorVejarano Orjuela, Álvaro
dc.date.accessioned2020-08-04T00:51:06Z
dc.date.available2020-08-04T00:51:06Z
dc.date.created2020-08-04T00:51:06Z
dc.date.issued2019-06-23
dc.identifierVejarano, O.A.
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/77910
dc.description.abstractIn order to identify and compare possible polymorphisms of the Luteinizing hormone receptor (LHR/LHCGR), the preovulatory follicle development (POF), the corpus luteum (CL) development and its progesterone (P4) secretion, as potential indicators of fertility in Romosinuano (RS) and Brahman (Br) breeds, an echographic follow up of ovarian dynamics during two consecutive estrous cycles (EC) was carried out in five females of each breed and their ovaries that contained the POF were surgically obtained. The POF was sectioned through its major diameter, as to obtain, from one half, histological preparations of 5 µm thick to calculate the volume occupied by the granulosa (GCV) and inner theca cells (ITCV). From the other half of the POF the total mRNA was extracted and the cDNA obtained as related to the gen that codifies for the LHCGR for sequential study in Macrogen. No differences were found (p>0.05) between the two breeds for the inter-estrous period, estrous duration, estrous – ovulation interval, the POF´s diameter, the GCV or TICV. Differences were encountered between breeds for the CL´s Diameter and the (P4) values at the seventh day of the estrous cycle. There was no correlation between corpus luteum diameter and (P4). The codding region of the LHCGR gen did not register variants related to the Gen Bank´s report in any of the 2 breeds studied. It is recommended to extend the present study to other physiological events, such as postpartum, by measuring the expression of the LHCGR gene and steroidogenesis in the same cell layers.
dc.description.abstractPara identificar y comparar posibles polimorfismos del gen del receptor de la hormona luteinizante (LHCGR), el desarrollo del folículo preovulatorio (FPO), el consecuente desarrollo del cuerpo lúteo (CL) y su secreción de progesterona (P4) como potenciales indicadores de fertilidad en bovinos Romosinuano (RS) y Brahman (Br), se realizó a cinco hembras de cada raza seguimiento ecográfico de la dinámica ovárica durante dos ciclos estrales consecutivos (CE); se obtuvieron quirúrgicamente los ovarios que contenían el FPO y este se seccionó diametralmente para obtener de una de las mitades preparados histológicos de 5 µm de grosor para calcular el volumen ocupado por la capa de células de la granulosa (VCG) y de la teca interna (VCTI). De la pared de la otra mitad del FPO se extrajo el ARNm total y se obtuvo el ADNc para el gen que codifica el LHCGR para secuenciación en Macrogen. No se encontraron diferencias significativas (p>0.05) entre las dos razas para periodo inter estros, duración del estro, intervalo estro – ovulación, el diámetro del FPO, ni para el VCG o VTI. No hubo correlación entre las variables Diámetro FPO y VCG o VCTI. Se hallaron diferencias en el diámetro del CL y (P4) en el día siete del CE. No se observó correlación entre DCL y (P4). La región codificante del gen LHCGR no registró variantes con respecto a los reportes del Gen Bank. Se recomienda ampliar el estudio a otros estados fisiológicos como el posparto, midiendo la expresión del gen del LHCGR y la esteroidogénesis en las mismas capas celulares.
dc.languagespa
dc.publisherBogotá - Medicina Veterinaria y de Zootecnia - Doctorado en Ciencias - Salud Animal o Producción Animal
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rightsAcceso abierto
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsDerechos reservados - Universidad Nacional de Colombia
dc.titleExpresión de receptores para la hormona luteinizante y su ácido ribonucléico mensajero en folículos preovulatorios de vacas Romosinuano y Brahman - posible relación con los niveles séricos de progesterona
dc.typeOtro


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