Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona

dc.contributorMartínez Rodríguez, Fleming
dc.contributorGrupo de Investigaciones Farmacéutico-Fisicoquímicas
dc.creatorOsorio Amado, Irmis Patricia
dc.date.accessioned2021-09-16T15:41:16Z
dc.date.available2021-09-16T15:41:16Z
dc.date.created2021-09-16T15:41:16Z
dc.date.issued2021-02
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/80215
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.description.abstractIn the present study, the solubility of sulfadiazine in aqueous mixtures of Carbitol and N-methyl-2-pyrrolidone (NMP) at 278.15 K - 313.15 K was analyzed. It was found that the solubility of sulfadiazine in aqueous Carbitol mixtures did not vary with temperature. For aqueous mixtures of NMP, it was found that the trend of the increase in solubility was different for rich mixtures in NMP. This could be by a possible phase change of the crystalline structure of sulfadiazine. The thermodynamic properties of solution, mixture and transfer were calculated. The preferential solvation parameters of sulfadiazine were determined using the experimental solubility values and the thermodynamic functions of solution by means of the inverse Kirkwood-Buff integrals (IKBI) method. For both cosolvent systems, it was found that sulfadiazine is preferentially solvated by water in water-rich mixtures, probably due to the hydrophobic hydration phenomenon, but preferentially solvated by Carbitol or NMP in cosolvent-rich mixtures, probably due to the behavior of sulfadiazine as Lewis acid in front of the cosolvent molecules. The enthalpy-entropy relationship of the (NMP + water) system was analyzed, finding a non-linear relationship by plotting the enthalpy of solution as a function of the Gibbs energy of solution. Finally, when evaluating the sulfadiazine solubility values calculated using the semi-empirical Jouyban-Acree and the extended Hildebrand models, notable deviations were obtained with respect to the experimental values. The smallest mean percentage deviations % MPD were achieved with the extended Hildebrand model using an order 5 polynomial, obtaining a value of 0.88% for the (Carbitol + water) system and 1.47% for the (NMP + water) system, both at 313.15 K.
dc.description.abstractEn el presente estudio se determinó la solubilidad de la sulfadiazina en mezclas acuosas de Carbitol y N-metil-pirrolidona (NMP) en el rango de temperaturas de 278,15 K a 313,15 K. Se encontró que la solubilidad de la sulfadiazina en mezclas acuosas de Carbitol no varió con la temperatura. Para la solubilidad de sulfadiazina en mezclas acuosas de NMP se encontró que la tendencia del aumento de solubilidad era diferente para mezclas ricas en NMP, lo que podría ser explicado por un posible cambio de fase de la estructura cristalina de la sulfadiazina. Se calcularon además las funciones termodinámicas aparentes de solución, mezcla y transferencia de dichos sistemas. Los parámetros de solvatación preferencial de la sulfadiazina se hallaron utilizando los valores de solubilidad experimentales y las funciones termodinámicas de solución por medio del método de las integrales inversas de Kirkwood-Buff (IKBI, Inverse Kirkwood-Buff Integrals). Para ambos sistemas de cosolventes, se encontró que la sulfadiazina es solvatada preferencialmente por agua en mezclas ricas en agua, debido probablemente al fenómeno de hidratación hidrofóbica, pero solvatada preferencialmente por Carbitol o NMP en mezclas ricas en cosolvente, debido probablemente al comportamiento de la sulfadiazina como ácido de Lewis frente a las moléculas de los cosolventes. Se analizó la relación entálpica-entrópica del sistema (NMP + agua) encontrando una relación no lineal al graficar la entalpía de solución en función de la energía de Gibbs de solución. Finalmente, al evaluar los valores de solubilidad de sulfadiazina calculados mediante los modelos semiempíricos de Jouyban-Acree y el modelo extendido de Hildebrand se obtuvieron desviaciones notables con respecto a los valores experimentales. Las menores desviaciones promedio porcentuales se lograron con el modelo extendido de Hildebrand utilizando un polinomio de orden 5 para calcular el factor W, obteniendo un porcentaje de 0,88% para el sistema (Carbitol + agua) y de 1,47% para el sistema (NMP + agua), ambos a 313,15 K. (Texto tomado de la fuente).
dc.languagespa
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Ciencias - Maestría en Ciencias Farmacéuticas
dc.publisherDepartamento de Farmacia
dc.publisherFacultad de Ciencias
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEstudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona
dc.typeTrabajo de grado - Maestría


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