Evaluación de la inflamación y la producción de IL-20 e IL-17ª en membrana sinovial en pacientes con osteoartritis de rodilla

dc.contributorRondón Herrera, Federico
dc.contributorRojas Rojas, Angela Patricia
dc.creatorNarvaez Reyes, María Isabel
dc.date.accessioned2020-02-17T13:43:58Z
dc.date.available2020-02-17T13:43:58Z
dc.date.created2020-02-17T13:43:58Z
dc.date.issued2020
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/75614
dc.description.abstractEl objetivo de este estudio es cuantificar y clasificar la gravedad de la inflamación en la sinovial de pacientes con osteoartritis de rodilla (OA) por escala cuantitativa a través de un estudio observacional descriptivo de series de casos. No se estimará el tamaño de la muestra para este estudio, todos los pacientes que tienen Se incluirá una indicación médica de un reemplazo de rodilla durante el período comprendido entre mayo de 2019 y julio de 2019. La presente serie de casos consta de 9 pacientes con un diagnóstico de artrosis de rodilla e indicación de reemplazo de articulación realizado entre mayo de 2018 y junio de 2019, con una edad promedio de 62.7 años (SD 16) al momento de la cirugía y el muestreo, la mayoría de los casos son mujeres 8 (88.9%), el peso promedio fue de 66.1 Kilos (SD 10.9) y un IMC de 27.8 (SD 4.8). Las principales comorbilidades incluyen presión arterial alta en 3 pacientes (33.3%), diabetes mellitus tipo 2 en dos casos (22%), casos de hipotiroidismo 3, casos de osteoporosis 2, osteoporosis 2 y un paciente (11%) con autoinmunidad debido a espondilitis anquilosante y uveítis; El número de pacientes con dos o más comorbilidades fue de 3 (33%). Demuestra un importante proceso inflamatorio asociado con la osteoartritis documentada histopatológicamente. La presencia de IL 20 e IL-17A es evidente en pacientes con osteoartritis que permite la cuantificación.
dc.description.abstractThe Objetive of this study is Quantify and classify the severity of inflammation in the synovium of patients with knee osteoarthritis (OA) by quantitative scale through an observational, descriptive case series study A sample size will not be estimated for this study, all patients who have a medical indication of a knee replacement during the period from May 2019 to July 2019 will be included The present case series consists of 9 patients with a diagnosis of knee OA and indication of joint replacement performed between May 2018 and June 2019, with an average age of 62.7 years (SD 16) at the time of surgery and sampling, the majority of the cases are female 8 (88.9%), average weight was 66.1 Kilos (SD 10.9) and BMI of 27.8 (SD 4.8). The main comorbidities include high blood pressure in 3 patients (33.3%), type 2 diabetes mellitus in two cases (22%), hypothyroidism 3 cases, osteoporosis 2 cases, osteoporosis 2 and one patient (11%) with autoimmunity due to ankylosing spondylitis and uveitis; The number of patients with two or more comorbidities was 3 (33%). It demonstrates an important inflammatory process associated with histopathologically documented osteoarthritis The presence of IL 20 and IL-17A is evident in patients with Osteoarthritis allowing quantification.
dc.languagespa
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rightsAcceso abierto
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsDerechos reservados - Universidad Nacional de Colombia
dc.titleEvaluación de la inflamación y la producción de IL-20 e IL-17ª en membrana sinovial en pacientes con osteoartritis de rodilla
dc.typeTrabajo de grado - Maestría


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