Multivariate characterization of brain dynamics for disorders of consciousness

dc.contributorGómez Jaramillo, Francisco
dc.contributorCastellanos, Gabriel
dc.contributorGrupo de Investigación en Modelado Computacional de Sistemas Biológicos (COMBIOS)
dc.creatorRudas Castaño, Jorge Eliécer
dc.date.accessioned2021-09-08T04:23:48Z
dc.date.available2021-09-08T04:23:48Z
dc.date.created2021-09-08T04:23:48Z
dc.date.issued2021-10
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/80127
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.description.abstractDespués de una lesión cerebral severa algunos pacientes pueden presentar alteraciones graves de la conciencia. Estas lesiones limitan grandemente la calidad de vida de estos pacientes y en consecuencia la de su familia. Las ultimas dos décadas han suscitado especial interés el entendimiento, descripción y caracterización de forma objetiva de la dinámica cerebral en este grupo de pacientes. La consecuencia inmediata de este entendimiento es la construcción de herramientas que permitan mejorar la toma de decisiones para los médicos que asisten o intervienen a estos pacientes. Múltiples estrategias han sido exploradas para ello, desde la construcción de rigurosas pruebas comportamentales hasta el uso de novedosas técnicas de neuroimágenes. Estas ultimas han mostrado un futuro prometedor para el contexto de estudio, alcanzando transcendentales hallazgos en relación al entendimiento de la emergencia de la conciencia, su alteración en estados comatosos y hasta han derivado en potenciales herramientas diagnosticas. Sin embargo y muy a pesar de estos importantes logros, aún existen múltiples retos por resolver en él área. Uno de esos retos fundamentales es la definición de un marco experimental adecuado para modelar la dinámica cerebral dada su abrumadora complejidad. Diversas estrategias han sido propuestas, sin embargo, aún permanece la imposibilidad de unificar en una única representación los agentes más relevantes para la emergencia de la conciencia. Es así como, en esta tesis doctoral se explora una aproximación en la representación de la dinámica cerebral que generaliza la noción de conectividad funcional entre unidades cerebrales. Los resultados aquí descritos se discuten en el marco de la caracterización de la dinámica cerebral de pacientes con desordenes de la conciencia, y su potencial uso como biomarcadores se resaltan en los resultados de esta tesis doctoral. (texto tomado de la fuente)
dc.description.abstractAfter a brain injury some patients may have severe disturbances in consciousness. These injuries greatly limit the quality of life of these patients and their families. The last two decades have raised special interest in the understanding, description and objective charac terization of brain dynamics in this group of patients. The immediate consequence of this understanding is the construction of tools that allow better decision-making for the phy sicians who assist or intervene these patients. Multiple strategies have been explored for this, from the construction of rigorous behavioral tests to the use of novel neuroimaging techniques. Neuroimaging approach have shown a promising future in this context, reaching transcendental findings in relation to the understanding of the emergence of consciousness, its alteration in comatose states and have even led to potential diagnostic tools. However, there are still many important challenges to overcome. One of these fundamental challenges is the definition of a suitable experimental framework to model brain dynamics, because the overwhelming complexity of this phenomena. Various strategies have been proposed, ho wever, the impossibility of unifying in a single representation the most relevant agents for the emergence of consciousness still remains as an open problem. Thus, this doctoral thesis explores an approach in the representation of brain dynamics that generalizes the notion of functional connectivity between brain units. The results described here are discussed within the framework of the characterization of the brain dynamics of patients with disorders of consciousness, and their potential use as biomarkers is highlighted in the results of this doc toral thesis.
dc.languagespa
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Ciencias - Doctorado en Biotecnología
dc.publisherInstituto de Biotecnología (IBUN)
dc.publisherFacultad de Ciencias
dc.publisherBogotá, Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-sa/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMultivariate characterization of brain dynamics for disorders of consciousness
dc.typeTrabajo de grado - Doctorado


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