dc.creator | Vargas Mora, Pablo | |
dc.creator | Peruilh-Bagolini, Leonardo | |
dc.creator | González Cuevas, Rubén | |
dc.creator | Ferrer Rosende, Pedro | |
dc.date.accessioned | 2021-10-01T18:39:15Z | |
dc.date.accessioned | 2022-01-27T21:58:45Z | |
dc.date.available | 2021-10-01T18:39:15Z | |
dc.date.available | 2022-01-27T21:58:45Z | |
dc.date.created | 2021-10-01T18:39:15Z | |
dc.date.issued | 2021 | |
dc.identifier | J Am Acad Dermatol 2021;85:128-34 | |
dc.identifier | 10.1016/j.jaad.2021.01.020 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/182135 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3317212 | |
dc.description.abstract | Background: Obtaining a sentinel lymph node biopsy (SLNB) specimen is a standard staging procedure in
the management of cutaneous melanoma. However, there is no consensus on the safe time interval
between the primary melanoma biopsy procedure and the SLNB procedure.
Objective: We evaluated the association between time from biopsy to SLNB and patients’ outcomes for
melanoma.
Methods: We performed this systematic review and meta-analysis based on the recommendations of the
Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results: Six retrospective studies were included. Nine thousand seven hundred five patients were
identified, of which 4383 underwent a SNLB procedure at a time interval defined as early and 4574 at an
interval defined as late. A combined hazard ratio of 1.25 (95% confidence interval [CI] 0.92-1.68) was
determined, and there was high heterogeneity (I2 = 83%; P = .002) of the SLNB time interval on melanoma-
specific survival. The combined HR for disease-free survival was 1.05 (95% CI 0.95-1.15), with low
heterogeneity (I2 = 9%; P = .36). Regarding overall survival, a combined HR of 1.25 (95% CI 0.92-1.70) was
found, with low heterogeneity (I2 = 37%; P = .2).
Limitations: There is heterogeneity between some studies.
Conclusion: There are no significant differences in patient outcome between a short interval versus a long
interval between the primary biopsy procedure and obtaining a SNLB specimen. | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | |
dc.source | Journal of the American Academy of Dermatology | |
dc.subject | Disease-free survival | |
dc.subject | Melanoma | |
dc.subject | Melanoma-specific survival | |
dc.subject | Overall survival | |
dc.subject | Sentinel lymph node biopsy | |
dc.subject | Timing of surgery | |
dc.title | Impact of the time interval between primary melanoma excision and sentinel node biopsy: A systematic review and meta-analysis | |
dc.type | Artículos de revistas | |