dc.creator | Peña Oyarzún, Daniel | |
dc.creator | Batista González, Ana | |
dc.creator | Kretschmar, Catalina | |
dc.creator | Burgos, Paulina | |
dc.creator | Lavandero González, Sergio | |
dc.creator | Morselli, Eugenia | |
dc.creator | Criollo Céspedes, Alfredo | |
dc.date.accessioned | 2021-08-04T23:32:12Z | |
dc.date.available | 2021-08-04T23:32:12Z | |
dc.date.created | 2021-08-04T23:32:12Z | |
dc.date.issued | 2020 | |
dc.identifier | International Review of Cell and Molecular Biology (2020) 354 Págs. 165-186 | |
dc.identifier | 10.1016/bs.ircmb.2020.02.006 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/181100 | |
dc.description.abstract | Polycystin-2 (PC2) is a calcium channel that can be found in the endoplasmic reticulum, the plasmatic
membrane, and the primary cilium. The structure of PC2 is characterized by a highly ordered C-terminal
tail with an EF-motif (calcium-binding domain) and a canonical coiled-coil domain (CCD; interaction
domain), and its activity is regulated by interacting partners and post-translational modifications.
Calcium mobilization into the cytosol by PC2 has been mainly associated with cell growth and
differentiation, and therefore mutations or dysfunction of PC2 lead to renal and cardiac consequences.
Interestingly, PC2-related pathologies are usually treated with rapamycin, an autophagy stimulator.
Autophagy is an intracellular degradation process where recycling material is sequestered into
autophagosomes and then hydrolyzed by fusion with a lysosome. Interestingly, several studies have
provided evidence that PC2 may be required for autophagy, suggesting that PC2 maintains a physiologic
catabolic state. | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.source | International Review of Cell and Molecular Biology | |
dc.subject | C-Terminal tail | |
dc.subject | EF-hand domain | |
dc.subject | Kidney-disease | |
dc.subject | Mediated phosphorylation | |
dc.subject | Channel polycystin-2 | |
dc.subject | Basal autophagy | |
dc.subject | Primary- Cilium | |
dc.subject | Protein | |
dc.subject | Receptor | |
dc.subject | Degradation | |
dc.title | New emerging roles of Polycystin-2 in the regulation of autophagy | |
dc.type | Artículo de revista | |