dc.creator | Pulgar, Eduardo | |
dc.creator | Schwayer, Cornelia | |
dc.creator | Guerrero, Néstor | |
dc.creator | López, Loreto | |
dc.creator | Márquez, Susana | |
dc.creator | Hartel, Steffen | |
dc.creator | Soto, Rodrigo | |
dc.creator | Heisenberg, Carl-Philipp | |
dc.creator | Concha Nordemann, Miguel Luis Angel | |
dc.date.accessioned | 2022-01-07T17:51:36Z | |
dc.date.accessioned | 2022-01-27T21:14:38Z | |
dc.date.available | 2022-01-07T17:51:36Z | |
dc.date.available | 2022-01-27T21:14:38Z | |
dc.date.created | 2022-01-07T17:51:36Z | |
dc.date.issued | 2021 | |
dc.identifier | eLife 2021;10:e66483 | |
dc.identifier | 10.7554/eLife.66483 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/183509 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3315323 | |
dc.description.abstract | The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. | |
dc.language | en | |
dc.publisher | Elife Sciences Publications | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | |
dc.source | eLife | |
dc.subject | Cell delamination | |
dc.subject | Apical constriction | |
dc.subject | Dragging | |
dc.subject | Mechanical forces | |
dc.subject | Collective locomotion | |
dc.subject | Dorsal forerunner cells | |
dc.subject | Zebrafish | |
dc.title | Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism | |
dc.type | Artículos de revistas | |