Artículo de revista
Counter- regulatory renin–angiotensin system in cardiovascular disease
Fecha
2020Registro en:
Nature Reviews Cardiology 17(2):116-129, 2020
10.1038/s41569-019-0244-8
Autor
Ocaranza, María Paz
Riquelme Meléndez, Jaime
García Nannig, Lorena
Jalil, Jorge
Chiong Lay, Mario
Santos, Robson
Lavandero González, Sergio
Institución
Resumen
The renin–angiotensin system is an important component of the cardiovascular
system. Mounting evidence suggests that the metabolic products of angiotensin I and II —
initially thought to be biologically inactive — have key roles in cardiovascular physiology and
pathophysiology. This non- canonical axis of the renin–angiotensin system consists of angiotensin
1–7 , angiotensin 1–9, angiotensin- converting enzyme 2, the type 2 angiotensin II receptor (AT2R),
the proto- oncogene Mas receptor and the Mas- related G protein- coupled receptor member D.
Each of these components has been shown to counteract the effects of the classical renin–
angiotensin system. This counter- regulatory renin–angiotensin system has a central role in the
pathogenesis and development of various cardiovascular diseases and, therefore, represents a
potential therapeutic target. In this Review , we provide the latest insights into the complexity
and interplay of the components of the non- canonical renin–angiotensin system, and discuss
the function and therapeutic potential of targeting this system to treat cardiovascular disease.