Plasma Tau Variants Detected by a Novel Anti-Tau Monoclonal Antibody: A Potential Biomarker for Alzheimer’s Disease

dc.creatorGonzález, Andrea
dc.creatorGuzmán Martínez, Leonardo
dc.creatorMaccioni Baraona, Ricardo
dc.date.accessioned2021-03-25T15:47:39Z
dc.date.available2021-03-25T15:47:39Z
dc.date.created2021-03-25T15:47:39Z
dc.date.issued2020
dc.identifierJ Alzheimers Dis . 2020;77(2):877-883
dc.identifier10.3233/JAD-200386
dc.identifierhttps://repositorio.uchile.cl/handle/2250/178796
dc.description.abstractBackground: A major drawback in Alzheimer's disease (AD) is the lack of validated biomarkers for routine clinical diagnostic. We have reported earlier a novel blood biomarker, named Alz-tau (R), based on variants of platelet tau. This marker evaluates the ratio of high molecular weight tau (HMWtau) and the low molecular weight (LMWtau) tau. Objective: To analyze a potential novel source of antigen for Alz-tau (R), plasma tau, detected by immunoreactivity with the novel monoclonal antibody, tau51. Methods: We evaluated tau variants in plasma precipitated with ammonium sulfate from 36 AD patients and 15 control subjects by western blot with this novel monoclonal antibody. Results: The HMW/LMWtau ratio was statistically different between AD patients and controls. Conclusions: Plasma tau variants are suitable to be considered as a novel antigen source for the Alz-tau (R) biomarker for AD.
dc.languageen
dc.publisherIOP Publishing
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceJournal of Alzheimer's Disease
dc.subjectAlz-tau®
dc.subjectAlzheimer’s disease
dc.subjectHMW/LMWtau ratio
dc.subjectMonoclonal antibodies
dc.subjectPeripheral biomarkers
dc.subjectTau protein in the human plasma
dc.titlePlasma Tau Variants Detected by a Novel Anti-Tau Monoclonal Antibody: A Potential Biomarker for Alzheimer’s Disease
dc.typeArtículo de revista


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