dc.creator | Greatti, Vanessa Raquel | |
dc.creator | Oda, Fernando | |
dc.creator | Sorrechia, Rodrigo | |
dc.creator | Kapp, Bárbara Regina | |
dc.creator | Seraphim, Carolina Manzato | |
dc.creator | Villas Boas Weckwerth, Ana Carolina | |
dc.creator | Chorilli, Marlus | |
dc.creator | Da Silva, Patricia Bento | |
dc.creator | Eloy, Josimar O. | |
dc.creator | Kogan, Marcelo J. | |
dc.creator | Morales Montecinos, Javier | |
dc.creator | Linhari Rodrigues Pietro, Rosemeire Cristina | |
dc.date.accessioned | 2021-06-24T21:58:26Z | |
dc.date.available | 2021-06-24T21:58:26Z | |
dc.date.created | 2021-06-24T21:58:26Z | |
dc.date.issued | 2020 | |
dc.identifier | Antibiotics 2020, 9, 894 | |
dc.identifier | 10.3390/antibiotics9120894 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/180254 | |
dc.description.abstract | Dermatophyte fungal infections are difficult to treat because they need long-term treatments. 4-Nerolidylcatechol (4-NC) is a compound found in Piper umbellatum that has been reported to demonstrate significant antifungal activity, but is easily oxidizable. Due to this characteristic, the incorporation in nanostructured systems represents a strategy to guarantee the compound's stability compared to the isolated form and the possibility of improving antifungal activity. The objective of this study was to incorporate 4-NC into polymeric nanoparticles to evaluate, in vitro and in vivo, the growth inhibition of Microsporum canis. 4-NC was isolated from fresh leaves of P. umbellatum, and polymer nanoparticles of polycaprolactone were developed by nanoprecipitation using a 1:5 weight ratio (drug:polymer). Nanoparticles exhibited excellent encapsulation efficiency, and the antifungal activity was observed in nanoparticles with 4-NC incorporated. Polymeric nanoparticles can be a strategy employed for decreased cytotoxicity, increasing the stability and solubility of substances, as well as improving the efficacy of 4-NC. | |
dc.language | en | |
dc.publisher | MDPI | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Antibiotics-Basel | |
dc.title | Poly-epsilon-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis | |
dc.type | Artículo de revista | |