dc.creator | Salamone, Paula C. | |
dc.creator | Legaz, Agustina | |
dc.creator | Sedeño, Lucas | |
dc.creator | Moguilner, Sebastián | |
dc.creator | Fraile Vázquez, Matías | |
dc.creator | González Campo, Cecilia | |
dc.creator | Fittipaldi, Sol | |
dc.creator | Yoris, Adrián | |
dc.creator | Miranda, Magdalena | |
dc.creator | Birba, Agustina | |
dc.creator | Galiani, Agostina | |
dc.creator | Abrevaya, Sofía | |
dc.creator | Neely Prado, Alejandra | |
dc.creator | Martorell Caro, Miguel | |
dc.creator | Alifano, Florencia | |
dc.creator | Villagra Castro, Roque Ariel | |
dc.creator | Anunziata, Florencia | |
dc.creator | Okada de Oliveira, Maira | |
dc.creator | Pautassi, Ricardo M. | |
dc.creator | Slachevsky Chonchol, Andrea Maria | |
dc.creator | Serrano, Cecilia | |
dc.creator | García, Adolfo M. | |
dc.creator | Ibañez, Agustín | |
dc.date.accessioned | 2022-01-20T18:20:51Z | |
dc.date.accessioned | 2022-01-27T19:25:07Z | |
dc.date.available | 2022-01-20T18:20:51Z | |
dc.date.available | 2022-01-27T19:25:07Z | |
dc.date.created | 2022-01-20T18:20:51Z | |
dc.date.issued | 2021 | |
dc.identifier | J. Neurosci, May 12, 2021 • 41(19):4276–4292 | |
dc.identifier | 10.1523/JNEUROSCI.2578-20.2021 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/183784 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3310498 | |
dc.description.abstract | Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of
negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and
exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive
and control-exteroceptive priming conditions followed by post-interoception and post-exteroception facial emotion recognition
(FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant
frontotemporal dementia (bvFTD), Parkinson’s disease (PD), and Alzheimer’s disease (AD). We measured online EEG modulations
of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity
patterns. Behaviorally, post-interoception negative FER was enhanced in HCs but selectively disrupted in bvFTD and
PD, with AD presenting generalized disruptions across emotion types. Only bvFTD presented impaired interoceptive accuracy.
Increased HEP modulations during post-interoception negative FER was observed in HCs and AD, but not in bvFTD or PD
patients. Across all groups, post-interoception negative FER correlated with the volume of the insula and the ACC. Also, negative
FER was associated with functional connectivity along the (a) salience network in the post-interoception condition, and
along the (b) executive network in the post-exteroception condition. These patterns were selectively disrupted in bvFTD (a)
and PD (b), respectively. Our approach underscores the multidimensional impact of interoception on emotion, while revealing
a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the
fields of nteroception, emotion, allostasis, and neurodegeneration. | |
dc.language | en | |
dc.publisher | Soc Neuroscience | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | |
dc.source | Journal of Neuroscience | |
dc.subject | Alzheimer’s disease | |
dc.subject | Behavioral variant frontotemporal dementia | |
dc.subject | Emotion | |
dc.subject | Interoception | |
dc.subject | Parkinson’s disease | |
dc.subject | Priming | |
dc.title | Interoception primes emotional processing: Multimodal evidence from neurodegeneration | |
dc.type | Artículos de revistas | |