dc.creator | Creusa Santos, Cleonice | |
dc.creator | Muñoz Casas del Valle, Patricia | |
dc.creator | Almeida, Áurea María A. N. | |
dc.creator | Pereira de Lima David, Juceni | |
dc.creator | Jorge Mauricio, David | |
dc.creator | Costa, Silvia Lima | |
dc.creator | Segura Aguilar, Juan | |
dc.creator | Amaral Silva, Víctor Diogenes | |
dc.date.accessioned | 2020-08-22T21:48:18Z | |
dc.date.available | 2020-08-22T21:48:18Z | |
dc.date.created | 2020-08-22T21:48:18Z | |
dc.date.issued | 2020 | |
dc.identifier | Neurotoxicity Research (2020) | |
dc.identifier | 10.1007/s12640-020-00237-6 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/176523 | |
dc.description.abstract | Flavonoids have been suggested to protect dopaminergic neurons in Parkinson’s disease based on studies that used exogenous
neurotoxins. In this study, we tested the protective ability of agathisflavone in SH-SY5Y cells exposed to the endogenous
neurotoxin aminochrome. The ability of aminochrome to induce loss of lysosome acidity is an important mechanism of its
neurotoxicity. We demonstrated that the flavonoid inhibited cellular death and lysosomal dysfunction induced by aminochrome.
In addition, we demonstrated that the protective effect of agathisflavone was suppressed by antagonists of estrogen receptors
(ERα and ERβ). These results suggest lysosomal protection and estrogen signaling as mechanisms involved in agathisflavone
neuroprotection in a Parkinson’s disease study model. | |
dc.language | en | |
dc.publisher | Springer | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Neurotoxicity Research | |
dc.subject | Parkinson’s disease | |
dc.subject | Dopamine | |
dc.subject | Flavonoid | |
dc.subject | Neuroprotection | |
dc.title | The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity | |
dc.type | Artículo de revista | |