dc.creatorCreusa Santos, Cleonice
dc.creatorMuñoz Casas del Valle, Patricia
dc.creatorAlmeida, Áurea María A. N.
dc.creatorPereira de Lima David, Juceni
dc.creatorJorge Mauricio, David
dc.creatorCosta, Silvia Lima
dc.creatorSegura Aguilar, Juan
dc.creatorAmaral Silva, Víctor Diogenes
dc.date.accessioned2020-08-22T21:48:18Z
dc.date.available2020-08-22T21:48:18Z
dc.date.created2020-08-22T21:48:18Z
dc.date.issued2020
dc.identifierNeurotoxicity Research (2020)
dc.identifier10.1007/s12640-020-00237-6
dc.identifierhttps://repositorio.uchile.cl/handle/2250/176523
dc.description.abstractFlavonoids have been suggested to protect dopaminergic neurons in Parkinson’s disease based on studies that used exogenous neurotoxins. In this study, we tested the protective ability of agathisflavone in SH-SY5Y cells exposed to the endogenous neurotoxin aminochrome. The ability of aminochrome to induce loss of lysosome acidity is an important mechanism of its neurotoxicity. We demonstrated that the flavonoid inhibited cellular death and lysosomal dysfunction induced by aminochrome. In addition, we demonstrated that the protective effect of agathisflavone was suppressed by antagonists of estrogen receptors (ERα and ERβ). These results suggest lysosomal protection and estrogen signaling as mechanisms involved in agathisflavone neuroprotection in a Parkinson’s disease study model.
dc.languageen
dc.publisherSpringer
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceNeurotoxicity Research
dc.subjectParkinson’s disease
dc.subjectDopamine
dc.subjectFlavonoid
dc.subjectNeuroprotection
dc.titleThe Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity
dc.typeArtículo de revista


Este ítem pertenece a la siguiente institución