Use of nPSi-beta CD Composite Microparticles for the Controlled Release of Caffeic Acid and Pinocembrin, Two Main Polyphenolic Compounds Found in a Chilean Propolis

dc.creatorGuzman Oyarzo, Dina
dc.creatorPlaza, Tanya
dc.creatorRecio Sánchez, Gonzalo
dc.creatorAbdalla, Dulcineia S. P.
dc.creatorSalazar, Luis A.
dc.creatorHernandez Montelongo, Jacobo
dc.date2019
dc.date2021-04-30T16:46:58Z
dc.date2021-04-30T16:46:58Z
dc.date.accessioned2021-06-14T22:08:42Z
dc.date.available2021-06-14T22:08:42Z
dc.identifierPHARMACEUTICS,Vol.11,,2019
dc.identifierhttp://repositoriodigital.uct.cl/handle/10925/3439
dc.identifier10.3390/pharmaceutics11060289
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3301528
dc.descriptionPropolis is widely recognized for its various therapeutic properties. These are attributed to its rich composition in polyphenols, which exhibit multiple biological properties (e.g., antioxidant, anti-inflammatory, anti-angiogenic). Despite its multiple benefits, oral administration of polyphenols results in low bioavailability at the action site. An alternative to face this problem is the use of biomaterials at nano-micro scale due to its high versatility as carriers and delivery systems of various drugs and biomolecules. The aim of this work is to determine if nPSi-beta CD microparticles are a suitable material for the load and controlled release of caffeic acid (CA) and pinocembrin (Pin), two of the main components of a Chilean propolis with anti-atherogenic and anti-angiogenic activity. Polyphenols and nPSi-beta CD microparticles cytocompatibility studies were carried out with human umbilical vein endothelial cells (HUVECs). Results from physicochemical characterization demonstrated nPSi-beta CD microparticles successfully retained and controlled release CA and Pin. Furthermore, nPSi-beta CD microparticles presented cytocompatibility with HUVECs culture at concentrations of 0.25 mg/mL. These results suggest that nPSi-beta CD microparticles could safely be used as an alternate oral delivery system to improve controlled release and bioavailability of CA or Pin-and eventually other polyphenols-thus enhancing its therapeutic effect for the treatment of different diseases.
dc.languageen
dc.publisherMDPI
dc.sourcePHARMACEUTICS
dc.subjectcontrolled release
dc.subjectnanoporous silicon
dc.subjectbeta CD polymer
dc.subjectcaffeic acid
dc.subjectpinocembrin
dc.subjectpolyphenols
dc.subjectHUVECs
dc.titleUse of nPSi-beta CD Composite Microparticles for the Controlled Release of Caffeic Acid and Pinocembrin, Two Main Polyphenolic Compounds Found in a Chilean Propolis
dc.typeArticle


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