Carbonate-beta-Cyclodextrin-Based Nanosponge as a Nanoencapsulation System for Piperine: Physicochemical Characterization

dc.creatorGarrido, B.
dc.creatorGonzalez, S.
dc.creatorHermosilla, J.
dc.creatorMillao, S.
dc.creatorQuilaqueo, M.
dc.creatorGuineo, J.
dc.creatorAcevedo, F.
dc.creatorPesenti Pérez, Héctor
dc.creatorRolleri, A.
dc.creatorShene, C.
dc.creatorRubilar, M.
dc.date2019
dc.date2021-04-30T16:47:47Z
dc.date2021-04-30T16:47:47Z
dc.date.accessioned2021-06-14T22:08:40Z
dc.date.available2021-06-14T22:08:40Z
dc.identifierJOURNAL OF SOIL SCIENCE AND PLANT NUTRITION,Vol.19,620-630,2019
dc.identifierhttp://repositoriodigital.uct.cl/handle/10925/3511
dc.identifier10.1007/s42729-019-00062-7
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3301514
dc.descriptionPiperine (PIP) is a nitrogenous substance whose application in food is still limited due to its low solubility in water, low bioavailability, and high pungency. Nanosponges (NS) can selectively capture, transport, and release a wide variety of substances and mask unpleasant flavors. The objective of this study was to evaluate carbonate-beta-cyclodextrin-based NS formation as a nanoencapsulation system for PIP. The NS were formed with a cyclic oligosaccharide (beta-cyclodextrin) to a cross-linker (diphenyl carbonate) at molar ratios of 1:2, 1:6, and 1:10 by the solvent method at 90, 120, and 150 degrees C for 5 h. Only molar ratios of 1:6 and 1:10 formed NS. The NS 1:6 at 90 degrees C with loading efficiency of 42.6% +/- 1.1 was the best alternative for loading PIP in the NS matrix because it had the lowest absorbance of cyclic carbonates and required the lowest amount of cross-linker in its formation. The ability of the cyclodextrin-based NS to encapsulate PIP was confirmed by FTIR studies and hyperspectral FTIR images, TGA, and DSC, showing that PIP is dispersed, not forming large clusters, or concentrating in a single zone. NS are an effective PIP encapsulation system and protect the bioactive properties of the PIP.
dc.languageen
dc.publisherSPRINGER INTERNATIONAL PUBLISHING AG
dc.sourceJOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
dc.subjectPiperine
dc.subjectbeta-Cyclodextrin
dc.subjectNanosponges
dc.subjectNanoencapsulation
dc.subjectSolvent method
dc.subjectInclusion complex
dc.titleCarbonate-beta-Cyclodextrin-Based Nanosponge as a Nanoencapsulation System for Piperine: Physicochemical Characterization
dc.typeArticle


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