Article
Recurrent respiratory papillomatosis in a pediatric patient: case report
Registro en:
REVISTA CHILENA DE PEDIATRIA-CHILE,Vol.88,393-397,2017
10.4067/S0370-41062017000300013
Autor
Benavente Muñoz, Felipe
Contreras, Marcelo
Perferi, Giancarlo
Azzari, Chiara
Munoz, Mariela
Inostroza, Jaime
Institución
Resumen
Introduction: Genetic variability related to the host immune system has been proposed as one of the most influential factors in the development of diseases caused by HPV. Clinical case: We report the case of a 5-year-old child in whom chronic laryngeal papillomatosis, probably acquired vertically during labor, was detected. The diagnosis of laryngeal papillomatosis was confirmed with a biopsy after a first surgery to remove the papillomas. The Derkay classification system was used to assess the severity of papillomatosis. Biopsy genotyping was performed by demonstrating HPV-6. Later, HLADQA1*0505, -DQB1*0301, -DRB1*1101 alleles were homozygous for HLA allele typing. Conclusions: Further studies are needed to identify the most prevalent HLA alleles in the Latino population and their potential association with genetic susceptibility in Recurrent Respiratory Papillomatosis.