| dc.contributor | Pérez Pérez, León Darío, dir. | |
| dc.contributor | Universidad de Ciencias Aplicadas y Ambientales, UDCA | |
| dc.creator | Rodríguez Molina, Yeimy Johana | |
| dc.date.accessioned | 2016-09-09T15:52:40Z | |
| dc.date.available | 2016-09-09T15:52:40Z | |
| dc.date.created | 2016-09-09T15:52:40Z | |
| dc.date.issued | 2016 | |
| dc.identifier | https://repository.udca.edu.co/handle/11158/565 | |
| dc.description.abstract | En el presente trabajo se estudió la síntesis de copolímeros en bloque anfifílicos basados en acrilato de colesterilo, acrilato de butilo y polietilenglicol mediante la técnica ARGET-ATRP, la polimerización fue confirmada empleando FT-IR, RMN1H, GPC y DSC. Adicionalmente, se estableció el efecto de la estructura de los copolímeros en el autoensamblaje en medio acuoso para la formación de micelas y sus propiedades coloidales mediante análisis de DLS, TEM y potencial Z. Finalmente, se estudió la capacidad de las micelas poliméricas bioconjugadas con colesterol, para encapsular y liberar anfotericina B (anfB) empleando espectroscopia UV/VIS.
De acuerdo a los resultados obtenidos, propiedades como el diámetro hidrodinámico y morfología de las micelas no se ven afectados por la composición de los copolímeros. Así mismo, al estudiar la encapsulación y liberación de anfB, se encontró que estas propiedades dependen en gran medida del carácter hidrofóbico del copolímero. Alcanzando mayor encapsulación del fármaco a medida que aumenta el contenido de colesterol, mientras que en los estudios de liberación se evidencio que a menor contenido de colesterol la liberación del fármaco es mayor. | |
| dc.language | spa | |
| dc.publisher | Facultad de Ciencias | |
| dc.publisher | Química | |
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| dc.rights | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.rights | Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) | |
| dc.rights | Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales | |
| dc.subject | Copolímeros Anfífilicos | |
| dc.subject | Colesterol | |
| dc.subject | Anfotericina B | |
| dc.title | Síntesis de copolímeros anfifílicos bioconjugados con colesterol y su aplicación en la encapsulación y liberación de anfotericina B | |
| dc.type | Trabajo de grado - Pregrado | |
