Sarcomere structure: The importance of desmin protein in muscle atrophy

Estructura de Sarcómera: La importancia de proteína desmina en atrofia muscular

dc.creatorMarzuca-Nassr, Gabriel
dc.creatorVitzel, Kaio Fernando
dc.creatorMancilla-Solorza, Eladio
dc.creatorMárquez, José Luis
dc.date2018-07-04T18:40:34Z
dc.date2018-07-04T18:40:34Z
dc.date2018
dc.date.accessioned2019-11-20T15:10:40Z
dc.date.available2019-11-20T15:10:40Z
dc.identifierhttp://repositorio.ucm.cl:8080/handle/ucm/1844
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3033572
dc.descriptionKnowing the ultrastructure of skeletal muscle is critical to understand how it works under normal situation and the disorders caused by extreme or pathological conditions. Sarcomere is the basic structural unit of striated muscle tissue. An important element of sarcomere architecture are the intermediate filaments, including the desmin protein. Desmin protein contributes to maintenance of cell integrity, efficient transmission of force and mechanochemical signaling within the myocyte. Because of this, desmin protein has constantly been a focus of research that investigates its alterations associated to damage and muscle atrophy under different conditions. The purpose of the following literature review is to describe the basic concepts of muscle ultrastructure, emphasizing the desmin protein role under conditions of muscle disuse atrophy and aging.
dc.languageen
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceInternational Journal of Morphology, 36(2), 576-583
dc.subjectSarcomere
dc.subjectDesmin
dc.subjectMuscle disuse atrophy
dc.subjectHindlimb suspension
dc.subjectAging
dc.subjectIntermediate filaments
dc.titleSarcomere structure: The importance of desmin protein in muscle atrophy
dc.titleEstructura de Sarcómera: La importancia de proteína desmina en atrofia muscular
dc.typeArtículos de revistas


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