dc.creatorSales, Francisco
dc.creatorPeralta, Oscar A.
dc.creatorNarbona, Eileen
dc.creatorMcCoard, Sue
dc.creatorLira, Raúl
dc.creatorReyes Solovera, Mónica de los
dc.creatorGonzález Bulnes, Antonio
dc.creatorParraguez Gamboa, Víctor
dc.date.accessioned2019-10-22T03:15:04Z
dc.date.available2019-10-22T03:15:04Z
dc.date.created2019-10-22T03:15:04Z
dc.date.issued2019
dc.identifierAntioxidants, Volumen 8, Issue 3, 2019,
dc.identifier20763921
dc.identifier10.3390/antiox8030059
dc.identifierhttps://repositorio.uchile.cl/handle/2250/172073
dc.description.abstractTwinning and maternal nutritional restriction leads to fetal hypoxia, oxidative stress, and intrauterine growth restriction (IUGR) in near-term sheep pregnancies. Our aim was to determine the effect of oral supplementation of vitamins C and E in pregnant sheep on maternal and umbilical cord blood concentrations of vitamins C and E and the effects on fetal antioxidant status, growth, and placental efficiency. Sixteen single- and sixteen twin-bearing ewes, grazing natural Patagonian prairies, were selected after transrectal ultrasound at day 30 after mating. Half of ewes from each pregnancy rank were supplemented daily with vitamins C and E, administered orally, from 30 to 140 days of gestation, when maternal jugular and fetal venous cord blood samples were obtained during cesarean section. Fetuses were weighed and sexed. Placental weight in each fetus was also obtained. Blood plasma was harvested for measurements of maternal and fetal vitamins concentration and fetal antioxidant capacity. Maternal administration of vitamin C and E was associated with increased fetal cord levels of both vitamins, improved antioxidant status, and enhanced fetal growth in both singleton and twin pregnancies associated with increased placental efficiency. These results highlight the potential of vitamin C and E supplementation to reduce the impact of IUGR in both livestock and humans.
dc.languageen
dc.publisherMDPI
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceAntioxidants
dc.subjectFetal antioxidant capacity
dc.subjectFetal growth
dc.subjectMaternal-fetal vitamins transfer
dc.titleMaternal supplementation with antioxidant vitamins in sheep results in increased transfer to the fetus and improvement of fetal antioxidant status and development
dc.typeArtículo de revista


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