Artículos de revistas
Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition
Fecha
2019Registro en:
Nutrition Reviews, Volumen 77, Issue 2, 2019, Pages 65-80
17534887
00296643
10.1093/nutrit/nuy047
Autor
Barra, Rafael
Morgan, Carlos
Sáez Briones, Patricio
Reyes Parada, Miguel
Burgos, Héctor
Morales, Bernardo
Hernández, Alejandro
Institución
Resumen
© The Author(s) 2018.Studies in rats have shown that a decrease in either protein content or total dietary calories results in molecular, structural, and functional changes in the cerebral cortex and hippocampus, among other brain regions, which lead to behavioral disturbances, including learning and memory deficits. The neurobiological bases underlying those effects depend at least in part on fetal programming of the developing brain, which in turn relies on epigenetic regulation of specific genes via stable and heritable modifications of chromatin. Prenatal malnutrition also leads to epigenetic programming of obesity, and obesity on its own can lead to poor cognitive performance in humans and experimental animals, complicating understanding of the factors involved in the fetal programming of neuroplasticity deficits. This review focuses on the role of epigenetic mechanisms involved in prenatal malnutrition-induced brain disturbances, which are apparent at a later postnatal age, throu