dc.creator | Catalan-Figueroa, Johanna | |
dc.creator | Boisset, Constanza B. | |
dc.creator | Jara, Miguel O. | |
dc.creator | Flores, Mario E. | |
dc.creator | Moreno-Villoslada, Ignacio | |
dc.creator | Fiedler, Jenny L. | |
dc.creator | Morales, Javier O. | |
dc.date.accessioned | 2019-03-18T12:03:49Z | |
dc.date.available | 2019-03-18T12:03:49Z | |
dc.date.created | 2019-03-18T12:03:49Z | |
dc.date.issued | 2018 | |
dc.identifier | European Journal of Pharmaceutical Sciences, Volumen 125, | |
dc.identifier | 18790720 | |
dc.identifier | 09280987 | |
dc.identifier | 10.1016/j.ejps.2018.10.002 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/167674 | |
dc.description.abstract | © 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In addition, ammonium methacrylate copolymers have shown to have mucoadhesive properties, whereas poloxamer 188, has been suggested as a Pgp inhibitor. Thus, in this work, we evaluate conditions that affect physicochemical parameters of ammonium methacrylate/poloxamer 188-based nanocarriers loaded with loperamide hydrochloride. Nanocarriers were synthesized by nanoprecipitation, enhancing loperamide encapsulation efficiency by modifying the aqueous phase to basic pH. The isolation of the non-encapsulated drug fraction from the nanocarriers-incorporated fraction was conducted by centrifugation, ultrafiltration, vacuum filtration and diafiltration. The last method was effective in providing a deeper understanding of drug-nanocarrier loading and interactions by means of modeli | |
dc.language | en | |
dc.publisher | Elsevier B.V. | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | European Journal of Pharmaceutical Sciences | |
dc.subject | Diafiltration | |
dc.subject | Eudragit RS® | |
dc.subject | Korsmeyer-Peppas | |
dc.subject | Loperamide | |
dc.subject | Makoid-Banakar | |
dc.subject | Poloxamer 188 | |
dc.title | A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages | |
dc.type | Artículo de revista | |