Artículos de revistas
Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies
Fecha
2018Registro en:
American Journal of Clinical Nutrition, Volumen 108, Issue 3, 2018, Pages 453-475
19383207
00029165
10.1093/ajcn/nqy107
Autor
Gielen, Marij
Hageman, Geja J.
Antoniou, Evangelia E.
Nordfjall, Katarina
Mangino, Massimo
Balasubramanyam, Muthuswamy
De Meyer, Tim
Hendricks, Audrey E.
Giltay, Erik J.
Hunt, Steven C.
Nettleton, Jennifer A.
Salpea, Klelia D.
Diaz, Vanessa A.
Farzaneh-Fa
Institución
Resumen
© 2018 American Society for Nutrition. Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Studyspecific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy