Artículo de revista
First trimester screening for preterm and term pre-eclampsia by maternal characteristics and biophysical markers in a low-risk population
Fecha
2018Autor
Sepúlveda-Martínez, Alvaro
Rencoret, Gustavo
Silva, María C.
Ahumada, Paz
Pedraza, Daniel
Muñoz, Hernán
Valdés, Enrique
Parra Cordero, Mauro
Institución
Resumen
© 2018 Japan Society of Obstetrics and Gynecology Aim: To develop a combined predictive model for preterm and term pre-eclampsia (PE) during the first trimester of pregnancy. Methods: This investigation was a nested case–control study in singleton pregnancies at the Maternal-Fetal Medicine Unit, University of Chile Hospital. A priori risks for preterm and term PE were calculated by multivariate logistic regression analyses. Biophysical markers were log10-transformed and expressed as multiples of the median. A multivariate logistic regression analysis was used to estimate a combined predictive model of preterm and term PE. Detection rates at different cut-off points were determined by a receiver operator curve analysis of a posteriori risks. Results: First trimester mean arterial pressure and uterine artery Doppler pulsatility index were significantly higher in women who develop PE than in the unaffected group. The detection rate of preterm PE based on maternal characteristics and bioph