dc.creatorHevia, Daniel
dc.creatorAraos, Patricio
dc.creatorRíos del Prado, Carolina Alejandra
dc.creatorLuppichini, Eugenia Fuentes
dc.creatorRojas, MacArena
dc.creatorAlzamora, Rodrigo
dc.creatorCifuentes-Araneda, Flavia
dc.creatorGonzález, Alexis A.
dc.creatorAmador, Cristian A.
dc.creatorPacheco, Rodrigo
dc.creatorMichea Acevedo, Luis
dc.date.accessioned2019-03-18T12:03:17Z
dc.date.available2019-03-18T12:03:17Z
dc.date.created2019-03-18T12:03:17Z
dc.date.issued2018
dc.identifierHypertension, Volumen 71, Issue 4, 2018, Pages 709-718
dc.identifier15244563
dc.identifier0194911X
dc.identifier10.1161/HYPERTENSIONAHA.117.10145
dc.identifierhttps://repositorio.uchile.cl/handle/2250/167584
dc.description.abstract© 2017 The Authors.Increasing evidence shows that antigen-presenting cells (APCs) are involved in the development of inflammation associated to hypertension. However, the potential role of APCs in the modulation of renal sodium transport has not been addressed. We hypothesized that APCs participate in renal sodium transport and, thus, development of high blood pressure in response to angiotensin II plus a high-salt diet. Using transgenic mice that allow the ablation of CD11chigh APCs, we studied renal sodium transport, the intrarenal renin-angiotensin system components, blood pressure, and cardiac/renal tissue damage in response to angiotensin II plus a high-salt diet. Strikingly, we found that APCs are required for the development of hypertension and that the ablation/restitution of APCs produces rapid changes in the blood pressure in mice with angiotensin II plus a high-salt diet. Moreover, APCs were necessary for the induction of intrarenal renin-angiotensin system components and af
dc.languageen
dc.publisherLippincott Williams and Wilkins
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceHypertension
dc.subjectAngiotensin II
dc.subjectAntigen-presenting cells
dc.subjectEpithelial sodium channel
dc.subjectHypertension
dc.subjectInflammation
dc.titleMyeloid CD11c+ antigen-presenting cells ablation prevents hypertension in response to angiotensin II plus high-salt diet
dc.typeArtículos de revistas


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