Artículos de revistas
Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects
Fecha
2018Registro en:
World Journal of Gastroenterology, Volumen 24, Issue 28, 2018, Pages 3071-3089
22192840
10079327
10.3748/wjg.v24.i28.3071
Autor
Bravo, Denisse
Hoare, Anilei
Soto, Cristopher
Valenzuela, Manuel A.
Quest, Andrew F. G.
Institución
Resumen
© The Author(s) 2018. Helicobacter pylori (H. pylori ) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated with different gastro-intestinal diseases, but also with extra gastric diseases. Despite such associations, the bacterium frequently persists in the human host without inducing disease, and it has been suggested that H. pylori may also play a beneficial role in health. To understand how H. pylori can produce such diverse effects in the human host, several studies have focused on understanding the local and systemic effects triggered by this bacterium. One of the main mechanisms by which H. pylori is thought to damage the host is by inducing local and systemic inflammation. However, more recently, studies are beginning to focus on the effects of H. pylori and its metabolism on the gastric and intestinal microbiome. The objective of this review is to discuss how H. pylo