dc.creatorGarcía Iniesta, Lucía; 634523
dc.creatorMARTINEZ CARRILLO, BEATRIZ ELINA; 227653
dc.creatorVALDES RAMOS, ROXANA; 13044
dc.creatorJARILLO LUNA, ROSA ADRIANA; 121532
dc.creatorESCOTO HERRERA, JORGE ALBERTO; 552156
dc.creatorRESENDIZ ALBOR, ALDO ARTURO; 202062
dc.creatorGarcía Iniesta, Lucía
dc.creatorMARTINEZ CARRILLO, BEATRIZ ELINA
dc.creatorVALDES RAMOS, ROXANA
dc.creatorJARILLO LUNA, ROSA ADRIANA
dc.creatorESCOTO HERRERA, JORGE ALBERTO
dc.creatorRESENDIZ ALBOR, ALDO ARTURO
dc.date2018-03-01T01:15:15Z
dc.date2018-03-01T01:15:15Z
dc.date2017-10-16
dc.date.accessioned2019-05-28T21:44:23Z
dc.date.available2019-05-28T21:44:23Z
dc.identifier2347-5641
dc.identifierhttp://hdl.handle.net/20.500.11799/71035
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2906106
dc.descriptionArtículo derivado de un proyecto de investigación para la identificación del efecto del consumo de edulcorantes sobre el sistema inmunitario.
dc.descriptionIntroduction: Modern lifestyles have changed eating habits, encouraged physical inactivity, and increased stress in daily life. These living conditions cause elevated concentrations of carbonylated proteins like biomarker of oxidative stress. The expression of this proteins represent irreversible damage to structural intracellular proteins in cells and extracellular matrix. It is not clear whether a rise in the concentration of these proteins is the origin or consequence of diseases. Objective: To determine in a healthy young mice model the possible correlation between prolonged sweetener consumption and the presence of chronic physiological stress, evidenced by the production of carbonylated proteins in peripheral blood lymphocytes. Methods: Sixty-four 21-day-old CD1 male mice were divided into two groups, stressed (with immobilization) and unstressed. Each group was divided into four subgroups: Control or experimental with a 6-week administration of sucrose, sucralose or stevia. Body mass index, food intake, number and concentration of carbonylated proteins, levels of glucose and peripheral lymphocytes in blood were evaluated. Data were analyzed with ANOVA. Results: Compared to the unstressed control, the glucose concentration was elevated in all stressed subgroups (F = 13.41, p < 0.01), with greater weight found in the stressed sucralose supplemented subgroup (F = 77.58, p < 0.001). The blood level of peripheral lymphocytes was above the control in all subgroups (F = 19.97, p < 0.01), except the decrease observed in unstressed sucrose supplemented subgroup. Carbonylated protein concentration in peripheral blood lymphocytes was high in all subgroups (versus the control) except in unstressed animals suppelemented with stevia (F = 51.16, p <0.01). Conclusions: Stress plus sucralose increased number of lymphocytes and carbonylated proteins concentration. The physiological stress with or without sweetener consumption generated increase in carbonylated proteins concentration. Stevia did not modify lymphocytes and carbonylated proteins.
dc.languageeng
dc.publisherScience Domain International
dc.rightsopenAccess
dc.rightshttp://creativecommons.org/licenses/by/4.0
dc.subjectproteínas carboniladas
dc.subjectestrés
dc.subjectlinfocitos
dc.subjectEdulcorantes
dc.subjectBIOLOGÍA Y QUÍMICA
dc.titleRelationship between prolonged sweetener consumption and chronic stress in the production of carbonylated proteins in blood lymphocytes
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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