INHIBITION OF ACETYLCHOLINESTERASE AND GLUTATHIONE‐S‐TRANFERASE ACTIVITIES BY METHANOLIC EXTRACT OF Lippia chevalieri MOLDENKE

dc.creatorMindiédiba, Jean Bangoua
dc.creatorBoukaré, Zeba
dc.creatorJ. Millogo, Rasolodimby
dc.creatorO. G. Nacoulma
dc.date.accessioned2015-01-14T17:03:41Z
dc.date.available2015-01-14T17:03:41Z
dc.date.created2015-01-14T17:03:41Z
dc.date.issued2014-06
dc.identifier2007-3127
dc.identifierhttp://www.repositoriodigital.ipn.mx/handle/123456789/20730
dc.description.abstractThe aim of the present study was to evaluate acetylcholinesterase (AChE) and glutathione‐S‐transferase (GST) inhibition against methanolic extract (100 μg/mL) of Lippia chevalieri from Burkina Faso. The total phenolics, flavonoids, flavonols and annins were also determined spectrophometrically. Lippia chevalieri inhibited both enzymes at more 35 %. The best inhibition activity was found on GST. The total phenolics content was 17.88 mg gallic acid equivalents (GAE)/100 mg dry extract. As tannins were the major phenolic compounds in the extracts, their contribution to inhibition activity could represent 42.61 %. The present findings suggest that the methanolic extract of L. chevalieri is a relevant inhibitor of AChE and GST and confirm its traditional use in the treatment of mental and respiratory disorders and cardiovascular diseases.
dc.languageen
dc.publisherVidsupra Vol.6 No.1
dc.subjectGlutation‐S‐transferasa, acetilcolinesterasa, extracto metanólico, Lippia chevalieri.
dc.titleINHIBITION OF ACETYLCHOLINESTERASE AND GLUTATHIONE‐S‐TRANFERASE ACTIVITIES BY METHANOLIC EXTRACT OF Lippia chevalieri MOLDENKE
dc.typeArticle


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