Thesis
EFECTO DEL SISTEMA NERVIOSO SIMPATICO EN EL TRANSPORTE Y SECRECION DE IgA EN LA MUCOSA INTESTINAL DE RATONES Balb/C
Autor
M. C. MEJÍA CORIA, JOSÉ MARTÍN
Institución
Resumen
The term stress is used to refer any condition that seriously perturbs
physiological and psychological homeostasis, and that the body perceives as a
threat. The stress response is controlled by the central nervous system (CNS),
endocrine and immune systems. It is generally accepted that acute stress may
enhance immune system function, while chronic stress results in reduced
immune responses. The purpose of this study was to determine the effect of the
sympathetic nervous system in the transport and secretion of IgA in the small
intestine of BALB / c under acute stress. Two groups of mice, one was
subjected to adrenergic receptor blockade and other chemical sympathectomy
was performed. Both groups evaluated the presence of SIgA in intestinal fluid
IgA and pIgR in epithelial cells by Western Blot. In the group which was
subjected to adrenergic receptor blockade observed in response to stress that
there is an increase in the levels of SIgA, IgA and pIgR. We also believe that
the observed increase in the levels of SIgA in most of the groups may be
mediated in part by increased intestinal permeability, which allows the
movement of IgA into the intestinal lumen from other parties other than the
intestinal lamina propria. In the group of mice that underwent chemical
sympathectomy observed that stress causes increased levels of SIgA, IgA and
Pig in response to stress, which does not reach the levels observed in the
control group more stress and can be given by the other hormones
(glucocorticoids in particular) that are generated in response to stress.