| dc.description.abstract | OBJECTIVE: To determine if the Polymorphism G-2548A of the LEP gene, A223G
of the LEPR gene and C34G of the PPARɣ gene, are genetic factors of risk for an
unfavorable outcome in secondary peritonitis.
MATERIAL AND METHODS: Prospective cohort. 75 patients of the service of
general surgery of the General Hospital of Durango, SSA were included, with
diagnose of peritonitis secondary non apendicular, confirmed surgically. Were
excluded patient with peritonitis apendicular, pancreatic peritonitis,
immonosuppressive treatment or chronic corticosteroids intake. Was done
extraction of DNA starting from total blood, PCR final point, and mutation specifies,
as well as RFLP.
RESULTS. 75 patients were includ (42♂ and 33♀), the age average of men
survivors was of 43 and 55 year-old of women surviors. A Body Mass Index (BMI)
average a total patients (24.20♀ and 23.6♂). Of the 75 patients, 22 died, and 53
survived.
Analysis of risks. The mutated allele (A) to polymorphism of the LEP gene
represents 4.64 times more non survival risk individuals with wild allele (G).
With regard to the polymorphism A223G of the gene LEPR, the presence of the
allele muted (G), suggests the possibility of a factor protective 3.5 times, however
the interval of trust is not definitive. The polymorphism C34G of the gene PPARɣ
doesn't represent a factor of risk for unfavorable outcome | |
