Efecto condroprotector de un menisco de 9 bioingeniería en un modelo animal de osteoartritis

Abstract

Background. Meniscus injuries represent the most common cause of arthroscopic surgery. Meniscectomy is a well-known risk factor for developing osteoarthritis (OA) of the knee. Meniscus transplants improve patient’s symptoms, but up to day, there is no evidence for delay the onset of knee OA. The main objective of this work is to generate a bioengineered meniscus implant, based on cell cultures to prevent the development of knee OA and to compare the efficacy and safety of different surgical procedures (bioengineered meniscus implant and autologous meniscus transplant) through the assessment of OA lesions, in a Sufolk sheep model. Main results, suggest that there is no solid evidence for the prevention of Knee OA with any of the procedures evaluated (meniscus transplant, bioengineering meniscus implant). However, the tissue found in bioengineered implants showed better ultrastructural features than that in autologous meniscus transplants. Minor complications in different surgical techniques such as arthrofibrosis, effusion and synovial hypertrophy were present, suggesting that there is a need to refine the surgical technique and peri-and postoperative management. Conclusion. There was no evidence of condroprotective effect of any of the surgical procederes evaluated in this study. We were able to recover meniscal tissue from our bioengineered implant.