| dc.description.abstract | Obesity is a chronic, complex and multifactorial induced genetic and environmental
components, an obese person is at risk for many diseases and health problems. Today,
Mexico ranks first inchildhood obesity and adult obesity in second in the world,
theNational Survey of Health and Nutrition (ENSANUT) 2005showed that the number of
obese people in Mexico has accelerated much faster than that estimated, due to the obesity
problem that triggers the development to be evaluated in detail.
The body mass index or BMI is the index most commonly used toestimate the percentage
of body fat in obese people, many articles point out as the most versatile for the simplicity
of its calculation, one of the strengths of estimating weight by BMI is80% correlated with
the amount of adipose tissue which correlates well in direct proportion to the risk of
disease.
Gene expression is regulated by interaction with the environment, there are several nuclear
receptors that function as transcription factors that regulate energy homeostasis and are key
genes inlipid metabolism and beta oxidation between these genes is thefamily PPARs,
which consists of three members, PPAR , PPAR PPAR PPARs to exert their
function usually form homodimers or heterodimers among themselves or with other nuclear
receptors. Other genes important in adipogenesisin lipid metabolism, inflammation and
apoptosis are also genes belonging to the family of orphanreceptors specifically including
the NR4As Nor1 and Nurr1 and Nurr 77.
In addition to these genes are important cofactors involved inlipid metabolism that are
essential to the functioning of genes, in the case of PPAR and are their cofactors
PGC1 PGC1 and in the case of NR4A family members is RIP140.
The number of biopsies used (n = 54) divided into three groups of 18 samples each
(thin, moderately obese and morbidly obese) should be increased and better established in
relation to a stratification of visceral adipose tissue biopsies and subcutaneous adipose tissue, which may represent betterstatistical significance. It seems that members of the
superfamily of nuclear receptors correlate gene expression level with differentbody
mass indexes, which has never been described and if confirmed would represent
a significant contribution to theunderstanding of adipose tissue metabolism possibly to
thepathogenesis of a complex disease such as obesity. | |
