Article
A Comparative Study of CYP3A4 Polymorphisms in Mexican Amerindian and Mestizo Populations
Fecha
2007-06-15Autor
Reyes Hernández, Octavio D.
Lares Asseff, Ismael
Sosa Macias, Martha
Vega, Libia
Albores, Arnulfo
Elizondo, Guillermo
Institución
Resumen
Cytochrome P-450 3A4 (CYP3A4) contributes to the metabolism
of approximately half the drugs in clinical use today. The
aim of the present study was to determine the frequency of
the CYP3A4 * 1B , * 2 , * 4 , * 5 , and * 18 alleles amongst both Tepehuan
Amerindians, a native group that has inhabited northern
Mexico for thousands of years, and Mestizo Mexicans,
and to compare the data with those of other populations.
Genotyping experiments revealed that 8.8 and 8.0% of the
Mestizo and Tepehuano subjects, respectively, carried the
CYP3A4 * 1B allele. Only one Mestizo subject was heterozygous
for the CYP3A4 * 2 variant, while CYP3A4 * 4 , * 5 and * 18
allelic variants were not detected in either group. On the
other hand, the frequencies of the CYP3A4 * 1B variant in Mestizos
and Tepehuanos were similar to those reported for
Caucasians, but different from those observed for African
and Asian populations.