dc.contributor | Kommers, Glaucia Denise | |
dc.contributor | http://lattes.cnpq.br/5818649889964582 | |
dc.contributor | Conrado, Luiz Francisco Irigoyen | |
dc.contributor | http://lattes.cnpq.br/2737077348044479 | |
dc.contributor | Fernandes, Cristina Gevehr | |
dc.contributor | http://lattes.cnpq.br/4498627593892325 | |
dc.contributor | Sallis, Eliza Simone Viégas | |
dc.contributor | http://lattes.cnpq.br/9207626698448838 | |
dc.contributor | Raffi, Margarida Buss | |
dc.contributor | http://lattes.cnpq.br/0778071474093717 | |
dc.creator | Trost, Maria Elisa | |
dc.date.accessioned | 2013-08-12 | |
dc.date.available | 2013-08-12 | |
dc.date.created | 2013-08-12 | |
dc.date.issued | 2013-02-19 | |
dc.identifier | TROST, Maria Elisa. Bone neoplasms and hypertrophic osteopathy in dogs. 2013. 76 f. Tese (Doutorado em Medicina Veterinária) - Universidade Federal de Santa Maria, Santa Maria, 2013. | |
dc.identifier | http://repositorio.ufsm.br/handle/1/4078 | |
dc.description.abstract | This doctoral thesis involved the study of three groups of neoplasms that affect bones of dogs (primary
bone neoplasms, bone metastases, and multicentric neoplasms with bone involvement) and a bone lesion, often
paraneoplastic, known as hypertrophic osteopathy. The study of primary bone neoplasms covered important
pathological and epidemiological aspects for the diagnosis of this group of tumors, with emphasis on
osteosarcomas. It was retrospectively performed, covering a period of 22 years. Reports of biopsy and necropsy
cases of dogs received at the Laboratório de Patologia Veterinária, Universidade Federal de Santa Maria (LPVUFSM)
were analyzed. Out of the 90 primary bone neoplasms diagnosed in this period, 89 were malignant.
Osteosarcoma was the most prevalent (86.7%) neoplasm. Regarding osteosarcomas, most cases occurred in large
and giant breed dogs, between six and 10 years of age. The neoplasms predominantly involved the appendicular
skeleton and were 3.5 times more prevalent in the forelimbs than in the hindlimbs. The predominant histologic
subtype was the osteoblastic. For the study of neoplasms that comprise the second and third groups, i.e.,
neoplasms with bone metastases or with bone involvement by multicentric neoplasms, a prospective study was
conducted over a period of three years. The skeleton of 110 dogs, with 118 malignant neoplasms of different
origins received in the necropsy service of the LPV-UFSM were examined for bone lesions. Twenty-one cases of
bone metastases or bone involvement by multicentric neoplasms (19.1%) were detected. In general, the bone
lesions affected more female dogs. However, when mammary gland neoplasms were not considered, the
distribution of cases according to the sex was very similar. The mean age was 9-years-old and dogs of different
breeds were affected. The mammary gland was the primary site of most bone metastases, followed by neoplasms
of the musculoskeletal and respiratory systems. Most metastases were observed grossly and occurred in multiple
bones. However, in 23% of the cases metastases could only be observed microscopically. Vertebrae and humerus
were the mosdt frequently affected bones. Simultaneously, seven cases of hypertrophic osteopathy, diagnosed in
a period of 11 years at the LPV-UFSM, were retrospectively and prospectively studied. Affected dogs had
clinical signs of bone involvement and lesions mainly in the long bones of the limbs. The lesions consisted of
periosteal bone neoformation, detected on radiographs, bone inspection during necropsy, and with great level of
detail, in macerated bone specimens. The bone proliferation was partially circumferential and occurred mainly in
the diaphysis of long bones. It consisted of bone trabeculae of irregular size and thickness, which were arranged
perpendicularly to the original cortical bone. In all cases, the lesions of hypertrophic osteopathy were associated
with lung neoplasms (primary or metastatic). In two of the seven cases, the lung metastases were of primary
bone sarcomas and, in one case, there was a primary lung osteosarcoma (extra-skeletic). | |
dc.publisher | Universidade Federal de Santa Maria | |
dc.publisher | BR | |
dc.publisher | Medicina Veterinária | |
dc.publisher | UFSM | |
dc.publisher | Programa de Pós-Graduação em Medicina Veterinária | |
dc.rights | Acesso Aberto | |
dc.subject | Neoplasmas ósseos primários | |
dc.subject | Metástases ósseas | |
dc.subject | Osteopatia hipertrófica | |
dc.subject | Patologia óssea | |
dc.subject | Doenças de cães | |
dc.subject | Primary bone neoplasms | |
dc.subject | Bone metastases | |
dc.subject | Hypertrophic osteopathy | |
dc.subject | Bone pathology | |
dc.subject | Diseases of dogs | |
dc.title | Neoplasmas ósseos e osteopatia hipertrófica em cães | |
dc.type | Tese | |