dc.contributor | Zeni, Gilson Rogério | |
dc.contributor | http://lattes.cnpq.br/2355575631197937 | |
dc.contributor | Ávila, Daiana Silva de | |
dc.contributor | http://lattes.cnpq.br/4355211015887363 | |
dc.contributor | Oliveira, Mauro Schneider | |
dc.contributor | http://lattes.cnpq.br/7132934163734175 | |
dc.creator | Bortolatto, Cristiani Folharini | |
dc.date.accessioned | 2012-09-21 | |
dc.date.available | 2012-09-21 | |
dc.date.created | 2012-09-21 | |
dc.date.issued | 2012-03-02 | |
dc.identifier | BORTOLATTO, Cristiani Folharini. 2,2'-Dithienyl diselenide, an organoselenium compound with antioxidant and neuroprotective activities in rats. 2012. 65 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Santa Maria, Santa Maria, 2012. | |
dc.identifier | http://repositorio.ufsm.br/handle/1/11186 | |
dc.description.abstract | Oxidative stress has been implicated in the pathophysiology of several neurological
diseases since the brain is an organ highly susceptible to oxidative damage. Temporal lobe
epilepsy (TLE) has been widely studied due to the high prevalence rate and refractoriness to
drug treatment. In addition, the ELT can be associated with psychiatric comorbidities, such as
depression. Since many organoselenium compounds have antioxidant and neuroprotective
properties, this study investigated the effects of 2,2'-dithienyl diselenide (DTDS) on seizures
induced by kainic acid (KA), an experimental model of TLE, as well as its antioxidant
potential in vitro and antidepressant-like activity in rats. The results showed that DTDS (100
mg/kg, per oral) reduced seizures induced by KA administration (10 mg/kg, intraperitoneal),
which were demonstrated by behavioral tests and electroencephalographic analysis. The
increase in the hippocampal content of reactive species and protein carbonylation as well as
the stimulation of Na+ K+ ATPase activity caused by KA were reduced by DTDS (50 and 100
mg/kg). In addition, DTDS (100 mg/kg) protected against hippocampal degeneration resulting
from exposure of rats to KA. DTDS, at low concentrations (μM range), reduced the content of
reactive species, protein carbonylation and lipid peroxidation in rat brain homogenate in vitro
and presented mimetic properties to dehydroascorbate (DHA) reductase and glutathione Stransferase
(GST), important enzymes for antioxidant function. The results also revealed that
DTDS was effective in inhibiting the activity of monoamine oxidase (MAO) A and B in rat
brain homogenate in vitro (25-100 μM) and in causing a reduction on immobility time of rats
in the forced swimming test (FST) (50 and 100 mg/kg, per oral). These findings suggest that
DTDS produced an anticonvulsant action in the KA model and attenuated the subsequent
oxidative damage and neuronal loss in hippocampus. Furthermore, the data showed that
DTDS had antioxidant and MAO non-selective inhibitor effects in rat brain in vitro and
antidepressant-like action in rats. Therefore, DTDS may be useful as a therapy for the
treatment of comorbidity ELT/depression. | |
dc.publisher | Universidade Federal de Santa Maria | |
dc.publisher | BR | |
dc.publisher | Bioquímica | |
dc.publisher | UFSM | |
dc.publisher | Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica | |
dc.rights | Acesso Aberto | |
dc.subject | Epilepsia do lobo temporal | |
dc.subject | Neurotoxicidade | |
dc.subject | Estresse oxidativo | |
dc.subject | Depressão | |
dc.subject | Selênio | |
dc.subject | Ratos | |
dc.subject | Temporal lobe epilepsy | |
dc.subject | Neurotoxicity | |
dc.subject | Oxidative stress | |
dc.subject | Depression | |
dc.subject | Selenium | |
dc.subject | Rats | |
dc.title | 2,2'-Disseleneto de ditienila, um composto orgânico de selênio com atividade antioxidante e neuroprotetora em ratos | |
dc.type | Dissertação | |