Síntese, análise estrutural e avaliação mimética da atividade catalítica da superóxido dismutase de complexos de cobre derivados de hidrazidas aromáticas

Abstract

This work presents the synthesis, characterization of copper (II) complexes and the potential of these compounds to mimic the catalytic activity of the enzyme superoxide dismutase. The complexes were obtained from the aldol condensation between substituted aromatic hydrazides and aromatic aldehydes (salicylic aldehyde and pyridoxal hydrochloride), resulting in eleven new copper (II) complexes. The complexes were structurally characterized by X-ray diffraction, cyclic voltammetry and complementary analysis. Subsequently, the compounds were evaluated for their antioxidant activities, using the NBT (Nitro blue tetrazolium chloride) photoreduction methodology. The results obtained for complexes derived from benzoic 4-amino hydrazide and benzoic 4- methoxy hydrazide with pyridoxal were considered promising for in vivo testing.