dc.contributor | Martins, Marcos Antonio Pinto | |
dc.contributor | http://lattes.cnpq.br/6457412713967642 | |
dc.contributor | Flores, Alex Fabiani Claro | |
dc.contributor | http://lattes.cnpq.br/1159954352174167 | |
dc.contributor | Zanatta, Nilo | |
dc.contributor | http://lattes.cnpq.br/0719465062354576 | |
dc.creator | Scapin, Elisandra | |
dc.date.accessioned | 2017-05-15 | |
dc.date.available | 2017-05-15 | |
dc.date.created | 2017-05-15 | |
dc.date.issued | 2006-01-27 | |
dc.identifier | SCAPIN, Elisandra. Pyrazolo[1,5-a]pirimidines : Synthesis and Bromation. 2006. 166 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2006. | |
dc.identifier | http://repositorio.ufsm.br/handle/1/10375 | |
dc.description.abstract | The synthesis of a series of 2-methyl-7-trichloromethylpyrazolo[1,5-a]pyrimidines from the cyclocondensation reaction of 3-amino-5-methylpyrazole with 1,1,1-trichloro-4- alkoxyalk-3-en-2-ones [CCl3C(O)CH=C(R1)OR where R1 = H, Me, Et, Pr, Bu, t-Bu e R = Me, Et] in good yields (69-98%) is reported. Also, was performed the synthesis of 2- methyl-7-arylpyrazolo[1,5-a]pyrimidines from de cyclocondensation reaction of 3-amino-5-methylpyrazole with β-dimethylaminovinyl ketones [R2C(O)CH=CHNMe2, where R= Ph, Ph-4-NO2, Ph-4-Me, Ph-4-Br, Ph-4-F, Ph-4-Cl, pyrid-2-yl, pyrrol-2-yil, tien-2-yl e fur- 2-yl] in good yields (65-98%). Finally, was performed of the bromation reaction of 2- methylpyrazolo[1,5-a]-pyrimidines from the reaction of these compounds with Nbromosuccinimide (yields: 70-98%). All compounds were obtained in satisfactory purity and were identified by 1H, 13C, HMQC and HMBC spectroscopy, CG-MS and X-ray diffraction. | |
dc.publisher | Universidade Federal de Santa Maria | |
dc.publisher | BR | |
dc.publisher | Química | |
dc.publisher | UFSM | |
dc.publisher | Programa de Pós-Graduação em Química | |
dc.rights | Acesso Aberto | |
dc.subject | Química | |
dc.subject | Química orgânica | |
dc.subject | Síntese orgânica | |
dc.subject | Bromação | |
dc.title | Pirazolo[1,5-a]pirimidinas: síntese e bromação | |
dc.type | Dissertação | |