Artigo
Heparan sulfate and cell division
Date
1999-05-01Registration in:
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 539-544, 1999.
0100-879X
S0100-879X1999000500006.pdf
S0100-879X1999000500006
10.1590/S0100-879X1999000500006
WOS:000080489600006
Author
Porcionatto, Marimélia Aparecida [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Dietrich, Carl Peter [UNIFESP]
Institutions
Abstract
Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic transformation. Several lines of experimental evidence suggest that heparan sulfate plays a role in cellular recognition, cellular adhesion and growth control. Heparan sulfate can participate in the process of cell division in two distinct ways, either as a positive or negative modulator of cellular proliferation, or as a response to a mitogenic stimulus.