Intratask Variability As a Correlate for DRD4 and SLC6A3 Variants: A Pilot Study in ADHD

dc.creatorVillarroel, Luis [Pontificia Universidad Católica de Chile]
dc.creatorHenriquez, Hugo [Chile. Universidad Mayor]
dc.creatorZamorano, Francisco [Pontificia Universidad Católica de Chile]
dc.date.accessioned2018-09-07T14:11:40Z
dc.date.accessioned2019-05-17T14:28:01Z
dc.date.available2018-09-07T14:11:40Z
dc.date.available2019-05-17T14:28:01Z
dc.date.created2018-09-07T14:11:40Z
dc.date.issued2015
dc.identifierHenríquez-Henríquez, M., Villarroel, L., Henríquez, H., Zamorano, F., Rothhammer, F., & Aboitiz, F. (2015). Intratask variability as a correlate for DRD4 and SLC6A3 variants: a pilot study in ADHD. Journal of attention disorders, 19(11), 987-996.
dc.identifierISSN 1087-0547
dc.identifierESSN 1557-1246
dc.identifierhttp://journals.sagepub.com/doi/abs/10.1177/1087054712455844?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
dc.identifierhttps://doi.org/10.1177/1087054712455844
dc.identifierhttps://www.researchgate.net/profile/Francisco_Zamorano/publication/230756818_Intratask_variability_as_a_correlate_for_DRD4_and_SLC6A3_variants_A_pilot_study_in_ADHD/links/565758ad08ae1ef9297bb61e.pdf
dc.identifierhttp://repositorio.umayor.cl/xmlui/handle/sibum/2715
dc.identifier10.1177/1087054712455844
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2672906
dc.description.abstractBehavioral variability may be an ADHD key feature. Currently used ex-Gaussian/Fast Fourier Transform analyses characterize general distribution and oscillatory/rhythmic components of performance but are unable to demonstrate slow cumulative changes over entire tasks. Objective: To explore how performance of ADHD children and unaffected sibs gradually evolves in relation to genetic variants linked to ADHD. Method: A total of 40 kids (20 ADHD-discordant sib pairs) between 8 and 13 years resolved a visual Go/NoGo with 10% NoGo probability. Variable number tandem repeats (VNTRs) at DRD4 and SLC6A3 were identified following standard protocols. Performance changes were assessed by linear/logistic mixed-effect models. Results: Models exploring SLC6A3 effects demonstrated less accentuated increments of response time (RT) (p = .046) and cumulative increments in the correct responses to NoGo (p = .00027) in 10R/10R participants. Models for DRD4 showed faster decline of correct responses to Go (p = .0078) in 2R/7R carriers. Conclusion: Dynamical analysis of attention/inhibition measures may unravel new correlates to DRD4 and SLC6A3 variants.
dc.languageen
dc.publisherCIENCIAS
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.subjectPSIQUIATRÍA
dc.titleIntratask Variability As a Correlate for DRD4 and SLC6A3 Variants: A Pilot Study in ADHD
dc.typeArtículos de revistas


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