Artículos de revistas
Caloric restriction and aging stem cells: The stick and the carrot?
Fecha
2014Registro en:
Mazzoccoli, G., Tevy, M. F., Borghesan, M., Delle Vergini, M. R., & Vinciguerra, M. (2014). Caloric restriction and aging stem cells: the stick and the carrot?. Experimental gerontology, 50, 137-148.
ISSN 0531-5565
ESSN 1873-6815
10.1016/j.exger.2013.10.014
Autor
Tevy, Maria Florencia [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]
Borghesan, Michela [IRCCS Scientific Institute]
Delle Vergini, Maria Rita [IRCCS Scientific Institute]
Vinciguerra, Manlio [IRCCS Scientific Institute]
Institución
Resumen
Adult tissue stem cells have the ability to adjust to environmental changes and affect also the proliferation of neighboring cells, with important consequences on tissue maintenance and regeneration. Stem cell renewal and proliferation is strongly regulated during aging of the organism. Caloric restriction is the most powerful anti-aging strategy conserved throughout evolution in the animal kingdom. Recent studies relate the properties of caloric restriction to its ability in reprogramming stem-like cell states and in prolonging the capacity of stem cells to self-renew, proliferate, differentiate, and replace cells in several adult tissues. However this general paradigm presents with exceptions. The scope of this review is to highlight how caloric restriction impacts on diverse stem cell compartments and, by doing so, might differentially delay aging in the tissues of lower and higher organisms.