Artículos de revistas
Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration
Fecha
2017-11Registro en:
Catenaccio A, Llavero Hurtado M, Diaz P, Lamont D, Wishart T, Court F. Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. Cell Death & Disease [serial on the Internet]. (2017, Nov 9), [cited May 10, 2018]; 8(11): e3166
2041-4889
WOS:000416931500003
ID de PubMed: 29120410
10.1038/cddis.2017.489
Autor
Catenaccio, Alejandra [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa]
Díaz, Paula [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa]
Lamont, Douglas J. [Reino Unido. University of Dundee. School of Life Sciences]
Wishart, Thomas M. [Reino Unido. University of Edinburgh. The Roslin Institute]
Hurtado, Maica Llavero [Reino Unido. University of Edinburgh. The Roslin Institute]
Court, Felipe A. [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa]
Institución
Resumen
Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction