Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

dc.contributorMax Planck Inst Psychiat
dc.contributorHarvard Med Sch
dc.contributorMcLean Hosp
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorHeidelberg Univ
dc.contributorHelmholtz Zentrum Munchen
dc.contributorTech Univ Munich
dc.contributorGerman Ctr Neurodegenerat Dis DZNE
dc.contributorMax Planck Gesell
dc.date.accessioned2018-11-26T16:01:21Z
dc.date.available2018-11-26T16:01:21Z
dc.date.created2018-11-26T16:01:21Z
dc.date.issued2018-06-01
dc.identifierNature Neuroscience. New York: Nature Publishing Group, v. 21, n. 6, p. 803-+, 2018.
dc.identifier1097-6256
dc.identifierhttp://hdl.handle.net/11449/160318
dc.identifier10.1038/s41593-018-0151-z
dc.identifierWOS:000433232600008
dc.description.abstractThe interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
dc.languageeng
dc.publisherNature Publishing Group
dc.relationNature Neuroscience
dc.relation15,207
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleChronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
dc.typeArtículos de revistas


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