Role of cholinergic and adrenergic pathways of the medial septal area in the control of water intake and renal excretion in rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:28Z
dc.date.available2014-05-27T11:17:28Z
dc.date.created2014-05-27T11:17:28Z
dc.date.issued1992-05-01
dc.identifierPharmacology, Biochemistry and Behavior, v. 42, n. 1, p. 1-8, 1992.
dc.identifier0091-3057
dc.identifierhttp://hdl.handle.net/11449/130654
dc.identifier10.1016/0091-3057(92)90437-K
dc.identifierWOS:A1992HZ47100001
dc.identifier2-s2.0-0026509136
dc.identifier6551236936295697
dc.identifier1023597870118105
dc.identifier339253755971890
dc.description.abstractIn this study, we investigated an interaction between noradrenergic and cholinergic pathways of the medial septal area (MSA) on the control of water intake and urinary electrolyte excretion by means of injection of their respective agonists. Noradrenaline (a nonspecific α-adrenergic agonist) and clonidine (an α2-adrenergic agonist), but not phenylephrine (an α1-adrenergic agonist), induced natriuresis and kaliuresis. α-Adrenergic activation had no effect on the natriuresis and kaliuresis induced by carbachol (a cholinergic agonist) and it inhibited the antinatriuresis and antikaliuresis induced by isoproterenol (a ß-adrenergic agonist). Interactions related to volume excretion are complex. α-Adrenergic activation induced a mild diuresis and inhibited the antidiuresis induced by isoproterenol, but phenylephrine combined with carbachol induced antidiuresis. The water intake induced by carbachol was inhibited by clonidine and noradrenaline, but not phenylephrine. These results show an asymmetry in the interaction between α-adrenergic and cholinergic receptors concerning water intake and electrolyte excretion. © 1992.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPharmacology Biochemistry and Behavior
dc.relation2.538
dc.relation1,150
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAdrenergic receptors
dc.subjectCholinergic receptors
dc.subjectDiuresis
dc.subjectKaliuresis
dc.subjectNatriuresis
dc.subjectThirst
dc.subjectWater intake
dc.subjectAlpha adrenergic receptor
dc.subjectBeta adrenergic receptor
dc.subjectCarbachol
dc.subjectCholinergic receptor stimulating agent
dc.subjectClonidine
dc.subjectIsoprenaline
dc.subjectNoradrenalin
dc.subjectPhenylephrine
dc.subjectAnimal experiment
dc.subjectAnimal tissue
dc.subjectControlled study
dc.subjectDiuresis
dc.subjectFluid intake
dc.subjectHistology
dc.subjectIntracerebral drug administration
dc.subjectKaliuresis
dc.subjectMale
dc.subjectNatriuresis
dc.subjectNonhuman
dc.subjectPriority journal
dc.subjectRat
dc.subjectSeptum nucleus
dc.subjectUrinary excretion
dc.subjectAnimal
dc.subjectCarbachol
dc.subjectClonidine
dc.subjectDrinking
dc.subjectIsoproterenol
dc.subjectKidney
dc.subjectMale
dc.subjectMesencephalon
dc.subjectNeural Pathways
dc.subjectNorepinephrine
dc.subjectParasympathetic Nervous System
dc.subjectPhenylephrine
dc.subjectPotassium
dc.subjectRats
dc.subjectSodium
dc.subjectSupport, Non-U.S. Gov't
dc.subjectSympathetic Nervous System
dc.subjectUrodynamics
dc.subjectAnimalia
dc.titleRole of cholinergic and adrenergic pathways of the medial septal area in the control of water intake and renal excretion in rats
dc.typeArtículos de revistas


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