dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:38Z
dc.date.available2014-05-27T11:23:38Z
dc.date.created2014-05-27T11:23:38Z
dc.date.issued2008-08-04
dc.identifierBrazilian Oral Research, v. 22, n. 2, p. 184-191, 2008.
dc.identifier1806-8324
dc.identifier1807-3107
dc.identifierhttp://hdl.handle.net/11449/70520
dc.identifier10.1590/S1806-83242008000200015
dc.identifierS1806-83242008000200015
dc.identifier2-s2.0-48249138149
dc.identifier2-s2.0-48249138149.pdf
dc.identifier1274225455678400
dc.description.abstractThis research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.
dc.languageeng
dc.relationBrazilian Oral Research
dc.relation1.223
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAlloxan
dc.subjectBone regeneration
dc.subjectDiabetes complications
dc.subjectDiabetes mellitus
dc.subjectalloxan
dc.subjectbiomaterial
dc.subjectpolitef
dc.subjectanalysis of variance
dc.subjectanimal
dc.subjectbone regeneration
dc.subjectchemically induced disorder
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectexperimental diabetes mellitus
dc.subjectpancreas
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectrabbit
dc.subjectrandomization
dc.subjectskull
dc.subjectwound healing
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBone Regeneration
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDisease Models, Animal
dc.subjectPancreas
dc.subjectParietal Bone
dc.subjectPolytetrafluoroethylene
dc.subjectRabbits
dc.subjectRandom Allocation
dc.subjectSkull
dc.subjectWound Healing
dc.titleBone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes
dc.typeArtículos de revistas


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