Artículos de revistas
Respiratory syncytial virus genotypes, host immune profles, and disease severity in young children hospitalized with bronchioliThis
Fecha
2018Registro en:
Journal of Infectious Diseases, Volumen 217, Issue 1, 2018, Pages 24-34
15376613
00221899
10.1093/infdis/jix543
Autor
Rodriguez-Fernandez, Rosa
Tapia, Lorena I.
Yang, Chin Fen
Torres, Juan Pablo
Chavez-Bueno, Susana
Garcia, Carla
Jaramillo, Lisa M.
Moore-Clingenpeel, Melissa
Jafri, Hasan S.
Peeples, Mark E.
Piedra, Pedro A.
Ramilo, Octavio
Mejias, Asuncion
Institución
Resumen
© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.Background. Data on how respiratory syncytial virus (RSV) genotypes influence disease severity and host immune responses is limited. Here, we characterized the genetic variability of RSV during 5 seasons, and evaluated the role of RSV subtypes, genotypes, and viral loads in disease severity and host transcriptional profles. Methods. A prospective, observational study was carried out, including a convenience sample of healthy infants hospitalized with RSV bronchioliThis. Nasopharyngeal samples for viral load quantitation, typing, and genotyping, and blood samples for transcriptome analyses were obtained within 24 hours of hospitalization. Multivariate models were constructed to identify virologic and clinical variables predictive of clinical outcomes. Results. We enrolled 253 infants (median age 2.1 [25%-75% interquartile range] months). RSV A infections predomi