Artículos de revistas
Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity?
Fecha
2017Registro en:
Frontiers in Molecular Neuroscience, Volumen 10,
16625099
10.3389/fnmol.2017.00374
Autor
Retamal, Mauricio A.
Riquelme, Manuel
Stehberg, Jimmy
Alcayaga Urbina, Julio
Institución
Resumen
© 2017 Retamal, Riquelme, Stehberg and Alcayaga.In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons. The somas of sensory neurons are located in sensory ganglia (i.e., trigeminal and nodose ganglia). It is well known that within sensory ganglia, sensory neurons do not form neither electrical nor chemical synapses. One of the reasons for this is that each soma is surrounded by glial cells, known as satellite glial cells (SGCs). Recent evidence shows that connexin43 (Cx43) hemichannels and probably pannexons located at SGCs have an important role in paracrine communication between glial cells and sensory neurons. This communication may be exerted via the release of bioactive molecules from SGCs and their subsequent action on receptors located at the soma of sensory neurons. The glio-neuronal communication seems to be relevant for the establishment of chronic pain, hyperalgesia and pathologies assoc