dc.creator | Santander, Nicolás | |
dc.creator | Lizama, Carlos | |
dc.creator | Parga, María José | |
dc.creator | Quiroz, Alonso | |
dc.creator | Pérez, Druso | |
dc.creator | Echeverría, Guadalupe | |
dc.creator | Ulloa, Lorena | |
dc.creator | Palma, Verónica | |
dc.creator | Rigotti, Attilio | |
dc.creator | Busso, Dolores | |
dc.date.accessioned | 2019-03-18T11:59:37Z | |
dc.date.available | 2019-03-18T11:59:37Z | |
dc.date.created | 2019-03-18T11:59:37Z | |
dc.date.issued | 2017 | |
dc.identifier | Scientific Reports, Volumen 7, Issue 1, 2018, | |
dc.identifier | 20452322 | |
dc.identifier | 10.1038/s41598-017-05422-w | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/167210 | |
dc.description.abstract | © 2017 The Author(s).SR-BI is the main receptor for high density lipoproteins (HDL) and mediates the bidirectional transport of lipids, such as cholesterol and Vitamin E, between these particles and cells. During early development, SR-BI is expressed in extraembryonic tissue, specifically in trophoblast giant cells in the parietal yolk sac. We previously showed that approximately 50% of SR-BI-/- embryos fail to close the anterior neural tube and develop exencephaly, a perinatal lethal condition. Here, we evaluated the role of SR-BI in embryonic Vitamin E uptake during murine neural tube closure. Our results showed that SR-BI-/- embryos had a very low Vitamin E content in comparison to SR-BI+/+ embryos. Whereas SR-BI-/- embryos with closed neural tubes (nSR-BI-/-) had high levels of reactive oxygen species (ROS), intermediate ROS levels between SR-BI+/+ and nSR-BI-/- embryos were detected in SR-BI-/- with NTD (NTD SR-BI-/-). Reduced expression of Pax3, Alx1 and Alx3 genes was found in N | |
dc.language | en | |
dc.publisher | Nature Publishing Group | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Scientific Reports | |
dc.subject | Multidisciplinary | |
dc.title | Deficient Vitamin E Uptake during Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI | |
dc.type | Artículos de revistas | |