Artículos de revistas
Angiogenesis and tumor progression inhibition of cyclooxygenase-2 selective inhibitor celecoxib associated with poly (Lactic-co-glycolic acid) in tumor cell line resistant to chemotherapy Inhibición de angiogénesis y progresión tumoral por inhibidor selec
Fecha
2017Registro en:
International Journal of Morphology, Volumen 35, Issue 2, 2018, Pages 733-739
07179502
07179367
10.4067/S0717-95022017000200055
Autor
Roa Henríquez, Ignacio
Cantín, Mario
Vilos, Cristian
Rosas, Carlos
Lemus, David
Institución
Resumen
© 2017, Universidad de la Frontera. All rights reserved. Although, antineoplastic therapies have now been developed reduction of tumor progression, it is necessary to find new therapeutic alternatives to suppress angiogenesis. Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lactic co-glycolic acid) (PLGA) acid, which help to improve the bioavailability and avoid effects of long drug administrations. For this purpose we used a murine tumor model induced by mammary adenocarcinoma cells resistant to chemotherapy (TA3-MTXR). CX/PLGA inhibits the microvascular density, VEGF expression and cell proliferation in addition to increased apoptosis (P <0.0001). Cx reduces tumor progression in a concentration of 1000 ppm associated with PLGA, reducing cell proliferation, the presence of VEGF and promoting apoptosis of multiresistant TA3 tumor cells.